Effects of beta-adrenergic antagonists in patients with chronic kidney disease: A systematic review and meta-analysis

Sunil Badve, Matthew Roberts, Carmel Hawley, Alan Cass, Amit Garg, Henry Krum, Andrew Tonkin, Vlado Perkovic

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105 Citations (Scopus)

Abstract

Objectives The aim of this systematic review was to study the benefits and risks of beta-adrenergic antagonists (betablockers) in patients with chronic kidney disease (CKD). Background There is an excess burden of cardiovascular disease and death in people with CKD. Despite their potential benefits, the effects of beta-blockers in this population are uncertain. Methods CENTRAL (Cochrane Central Register of Controlled Trials), Medline (Medical Literature Analysis and Retrieval System Online), and Embase (Excerpta Medical Database) were searched for randomized controlled trials with at least 3 months of follow-up in patients with CKD stages 3 to 5 that reported mortality outcomes. Summary estimates of effect were obtained using a random effects model. Results Eight trials met criteria for review: 6 placebo-controlled trials involving 5,972 participants with chronic systolic heart failure and 2 angiotensin-converting enzyme inhibitora??comparator trials involving 977 participants not known to have heart failure. In CKD patients with heart failure, compared with placebo, betablocker treatment reduced the risk of all-cause (risk ratio [RR]: 0.72, 95 confidence interval [CI]: 0.64 to 0.80) and cardiovascular mortality (RR: 0.66, 95 CI: 0.49 to 0.89), but increased the risk of bradycardia (RR: 4.92, 95 CI: 3.20 to 7.55) and hypotension (RR: 5.08, 95 CI: 3.48 to 7.41). Quantitative metaanalysis was not performed for the nona??heart failure studies due to substantial clinical diversity or lack of informative data. Conclusions Treatment with beta-blockers improved all-cause mortality in patients with CKD and chronic systolic heart failure. There is insufficient evidence to conclude whether people with CKD who are not known to have heart failure derive benefit from beta-blockers. (J Am Coll Cardiol 2011;58:1152a??61) A? 2011 by the American College of Cardiology Foundation
Original languageEnglish
Pages (from-to)1152 - 1161
Number of pages10
JournalJournal of the American College of Cardiology
Volume58
Issue number11
DOIs
Publication statusPublished - 2011

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