Effects of Antibody on Viral Kinetics in Simian/Human Immunodeficiency Virus Infection: Implications for Vaccination

Lei Zhang, Ruy M. Ribeiro, John R. Mascola, Mark G. Lewis, Gabriela Stiegler, Hermann Katinger, Alan S. Perelson, Miles P. Davenport

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Abstract

Passive antibody treatment of macaques prior to simian/human immunodeficiency virus infection produces "sterilizing immunity" in some animals and long-term reductions in viral loads in others. Analysis of viral kinetics suggests that antibody mediates sterilizing immunity by its effects on the initial viral inoculum. By contrast, reduction in peak viral load later in infection prevents CD4 depletion and contributes to long-term viral control.

Original languageEnglish
Pages (from-to)5520-5522
Number of pages3
JournalJournal of Virology
Volume78
Issue number10
DOIs
Publication statusPublished - May 2004
Externally publishedYes

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