Effects of annexin V on the activity of the anticoagulant proteins C and S

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Abstract

The effects of annexin V on the anticoagulant activity of activated protein C (APC) and protein S were examined. Although annexin V did not influence the amidolytic potential of APC, it inhibited both APC and protein S function in a factor Va inactivation assay. Competition experiments demonstrated that annexin V inhibits protein S binding to phospholipid vesicles in a dose-dependent manner. These results demonstrate that annexin V effectively interferes with the anticoagulant arm of the hemostatic system.

Original languageEnglish
Pages (from-to)279-287
Number of pages9
JournalThrombosis Research
Volume69
Issue number3
DOIs
Publication statusPublished - 1 Feb 1993
Externally publishedYes

Keywords

  • annexin V
  • Anticoagulants
  • protein C
  • protein S

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