Effects of annexin V on the activity of the anticoagulant proteins C and S

Jiuru Sun; Phillip Bird; Hatem H. Salem

doi:10.1016/0049-3848(93)90025-J

Effects of annexin V on the activity of the anticoagulant proteins C and S

Jiuru Sun, Phillip Bird, Hatem H. Salem

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

Abstract

The effects of annexin V on the anticoagulant activity of activated protein C (APC) and protein S were examined. Although annexin V did not influence the amidolytic potential of APC, it inhibited both APC and protein S function in a factor Va inactivation assay. Competition experiments demonstrated that annexin V inhibits protein S binding to phospholipid vesicles in a dose-dependent manner. These results demonstrate that annexin V effectively interferes with the anticoagulant arm of the hemostatic system.

Original language	English
Pages (from-to)	279-287
Number of pages	9
Journal	Thrombosis Research
Volume	69
Issue number	3
DOIs	https://doi.org/10.1016/0049-3848(93)90025-J
Publication status	Published - 1 Feb 1993
Externally published	Yes

Keywords

annexin V
Anticoagulants
protein C
protein S

Access to Document

10.1016/0049-3848(93)90025-J

Cite this

@article{1a7334efc6b54f4b815bdaa704bd29d2,

title = "Effects of annexin V on the activity of the anticoagulant proteins C and S",

abstract = "The effects of annexin V on the anticoagulant activity of activated protein C (APC) and protein S were examined. Although annexin V did not influence the amidolytic potential of APC, it inhibited both APC and protein S function in a factor Va inactivation assay. Competition experiments demonstrated that annexin V inhibits protein S binding to phospholipid vesicles in a dose-dependent manner. These results demonstrate that annexin V effectively interferes with the anticoagulant arm of the hemostatic system.",

keywords = "annexin V, Anticoagulants, protein C, protein S",

author = "Jiuru Sun and Phillip Bird and Salem, {Hatem H.}",

year = "1993",

month = feb,

day = "1",

doi = "10.1016/0049-3848(93)90025-J",

language = "English",

volume = "69",

pages = "279--287",

journal = "Thrombosis Research",

issn = "0049-3848",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Effects of annexin V on the activity of the anticoagulant proteins C and S

AU - Sun, Jiuru

AU - Bird, Phillip

AU - Salem, Hatem H.

PY - 1993/2/1

Y1 - 1993/2/1

N2 - The effects of annexin V on the anticoagulant activity of activated protein C (APC) and protein S were examined. Although annexin V did not influence the amidolytic potential of APC, it inhibited both APC and protein S function in a factor Va inactivation assay. Competition experiments demonstrated that annexin V inhibits protein S binding to phospholipid vesicles in a dose-dependent manner. These results demonstrate that annexin V effectively interferes with the anticoagulant arm of the hemostatic system.

AB - The effects of annexin V on the anticoagulant activity of activated protein C (APC) and protein S were examined. Although annexin V did not influence the amidolytic potential of APC, it inhibited both APC and protein S function in a factor Va inactivation assay. Competition experiments demonstrated that annexin V inhibits protein S binding to phospholipid vesicles in a dose-dependent manner. These results demonstrate that annexin V effectively interferes with the anticoagulant arm of the hemostatic system.

KW - annexin V

KW - Anticoagulants

KW - protein C

KW - protein S

UR - http://www.scopus.com/inward/record.url?scp=0027414706&partnerID=8YFLogxK

U2 - 10.1016/0049-3848(93)90025-J

DO - 10.1016/0049-3848(93)90025-J

M3 - Article

C2 - 8475478

AN - SCOPUS:0027414706

SN - 0049-3848

VL - 69

SP - 279

EP - 287

JO - Thrombosis Research

JF - Thrombosis Research

IS - 3

ER -

Effects of annexin V on the activity of the anticoagulant proteins C and S

Abstract

Keywords

Access to Document

Other files and links

Cite this