Effects of annexin V on the activity of the anticoagulant proteins C and S

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

The effects of annexin V on the anticoagulant activity of activated protein C (APC) and protein S were examined. Although annexin V did not influence the amidolytic potential of APC, it inhibited both APC and protein S function in a factor Va inactivation assay. Competition experiments demonstrated that annexin V inhibits protein S binding to phospholipid vesicles in a dose-dependent manner. These results demonstrate that annexin V effectively interferes with the anticoagulant arm of the hemostatic system.

Original languageEnglish
Pages (from-to)279-287
Number of pages9
JournalThrombosis Research
Volume69
Issue number3
DOIs
Publication statusPublished - 1 Feb 1993
Externally publishedYes

Keywords

  • annexin V
  • Anticoagulants
  • protein C
  • protein S

Cite this

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abstract = "The effects of annexin V on the anticoagulant activity of activated protein C (APC) and protein S were examined. Although annexin V did not influence the amidolytic potential of APC, it inhibited both APC and protein S function in a factor Va inactivation assay. Competition experiments demonstrated that annexin V inhibits protein S binding to phospholipid vesicles in a dose-dependent manner. These results demonstrate that annexin V effectively interferes with the anticoagulant arm of the hemostatic system.",
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Effects of annexin V on the activity of the anticoagulant proteins C and S. / Sun, Jiuru; Bird, Phillip; Salem, Hatem H.

In: Thrombosis Research, Vol. 69, No. 3, 01.02.1993, p. 279-287.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Sun, Jiuru

AU - Bird, Phillip

AU - Salem, Hatem H.

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N2 - The effects of annexin V on the anticoagulant activity of activated protein C (APC) and protein S were examined. Although annexin V did not influence the amidolytic potential of APC, it inhibited both APC and protein S function in a factor Va inactivation assay. Competition experiments demonstrated that annexin V inhibits protein S binding to phospholipid vesicles in a dose-dependent manner. These results demonstrate that annexin V effectively interferes with the anticoagulant arm of the hemostatic system.

AB - The effects of annexin V on the anticoagulant activity of activated protein C (APC) and protein S were examined. Although annexin V did not influence the amidolytic potential of APC, it inhibited both APC and protein S function in a factor Va inactivation assay. Competition experiments demonstrated that annexin V inhibits protein S binding to phospholipid vesicles in a dose-dependent manner. These results demonstrate that annexin V effectively interferes with the anticoagulant arm of the hemostatic system.

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