Effects of abacavir administration on structural and functional markers of platelet activation

Janine Maree Trevillyan, Jane Frances Arthur, Jing Jing, Robert Keith Andrews, Elizabeth Ellen Gardiner, Jennifer Frances Hoy

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6 Citations (Scopus)

Abstract

Current abacavir exposure has been reported to be associated with cardiovascular disease. Changes in platelet reactivity could plausibly explain the clinically observed pattern of association. Objective: To determine if platelet reactivity changed following abacavir exposure and whether this effect was reversible on cessation of the drug. Methods: In an open-label, interventional study abacavir, 600 mg daily, was added to a suppressive antiretroviral regimen in 20 adult HIV-positive men. Platelet function, estimated by the phosphorylated vasodilator-stimulated phosphoprotein (P-VASP) assay and through measurement of the expression and shedding of platelet-specific receptors, was assessed at baseline, following 15 days of abacavir and at completion of a 28-day washout period. Results: The VASP-index decreased significantly from 79.1 [interquartile range (IQR) 47.8-87.6] to 32.6 (IQR -11.5-51.0) following 15 days of abacavir administration (P = 0.010), and returned to baseline levels following the washout period (day 43 =76.3 ; IQR 40.7-92.3). There was no change in resting (prostaglandin E1 alone) P-VASP but a slight increase in P-VASP within stimulated platelets (prostaglandin E1 and adenosine diphosphate). Integrin ?3 levels decreased significantly [208.5 ng/ml (IQR 177.0-231.1) to 177.5 ng/ml (IQR 151.7-205) P
Original languageEnglish
Pages (from-to)2309 - 2313
Number of pages5
JournalAIDS
Volume29
Issue number17
DOIs
Publication statusPublished - 2015

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