TY - JOUR
T1 - Effects and mechanisms of computerized cognitive training in Huntington's disease
T2 - protocol for a pilot study
AU - Huynh, Katharine
AU - Jamadar, Sharna
AU - Stout, Julie
AU - Voigt, Katharina
AU - Lampit, Amit
AU - Georgiou-Karistianis, Nellie
N1 - Funding Information:
This study is funded by Monash University (PAG19-0576) and Huntington's Victoria (2022 Peter Walsh Scholarship). K Huynh is supported by an Australian Government Research Training Program (RTP) Scholarship. S Jamadar is supported by an Australian National Health and Medical Research Council (NHMRC) Fellowship (APP1174164). A Lampit is supported by the University of Melbourne. The funders have no involvement in the design, conduct, analysis and reporting of the study. All researchers and personnel have no conflicts of interest to declare. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Publisher Copyright:
© 2024 The Authors.
PY - 2024
Y1 - 2024
N2 - Huntington's disease (HD) causes progressive cognitive decline, with no available treatments. Computerized cognitive training (CCT) has shown efficacy in other populations, but its effects in HD are largely unknown. This pilot study will explore the effects and neural mechanisms of CCT in HD. The intervention group participants will complete 12 weeks of multidomain CCT. Control group participants will receive lifestyle education and access to CCT after the study. The primary outcome is change in processing speed. Secondary outcomes include–change in other cognitive domains, functional brain network connectivity (derived from MRI) and psychosocial function. Feasibility outcomes include rates of recruitment, adherence and retention. This study may provide insights into the effects of CCT in HD and guide future trials. Clinical Trial Registration: ACTRN12622000908730 (ClinicalTrials.gov).
AB - Huntington's disease (HD) causes progressive cognitive decline, with no available treatments. Computerized cognitive training (CCT) has shown efficacy in other populations, but its effects in HD are largely unknown. This pilot study will explore the effects and neural mechanisms of CCT in HD. The intervention group participants will complete 12 weeks of multidomain CCT. Control group participants will receive lifestyle education and access to CCT after the study. The primary outcome is change in processing speed. Secondary outcomes include–change in other cognitive domains, functional brain network connectivity (derived from MRI) and psychosocial function. Feasibility outcomes include rates of recruitment, adherence and retention. This study may provide insights into the effects of CCT in HD and guide future trials. Clinical Trial Registration: ACTRN12622000908730 (ClinicalTrials.gov).
KW - cognition
KW - cognitive training
KW - functional connectivity
KW - Huntington's disease
KW - randomized controlled trial
UR - https://www.scopus.com/pages/publications/85193599245
U2 - 10.2217/nmt-2023-0001
DO - 10.2217/nmt-2023-0001
M3 - Article
C2 - 39781626
AN - SCOPUS:85193599245
SN - 1758-2024
VL - 14
SP - 203
EP - 216
JO - Neurodegenerative Disease Management
JF - Neurodegenerative Disease Management
IS - 6
ER -