TY - JOUR
T1 - Effectiveness of Interventions Targeting Treatable Traits for the Management of Obstructive Airway Diseases
T2 - A Systematic Review and Meta-Analysis
AU - Sarwar, Muhammad Rehan
AU - McDonald, Vanessa Marie
AU - Abramson, Michael John
AU - McLoughlin, Rebecca Frances
AU - Geethadevi, Gopisankar Mohanannair
AU - George, Johnson
N1 - Funding Information:
Conflicts of Interest: M. J. Abramson and J. George hold or have held investigator initiated grants from GSK, Pfizer, and Boehringer Ingelheim for unrelated research. V. M. McDonald has received research funding from AstraZeneca, Cyclopharm, GSK, NHMRC, and Ramaciotti; speaker's honoraria from AstraZeneca and GSK; and provided consultancy for AstraZeneca, GSK, and Menarini. M. J. Abramson has undertaken an unrelated consultancy for and received assistance with conference attendance from Sanofi. He has also received a speaker's fee from GSK. The rest of the authors declare that they have no relevant conflicts of interest. No funding was received for this work.
Funding Information:
Conflicts of Interest: M. J. Abramson and J. George hold or have held investigator initiated grants from GSK , Pfizer , and Boehringer Ingelheim for unrelated research. V. M. McDonald has received research funding from AstraZeneca , Cyclopharm , GSK , NHMRC , and Ramaciotti ; speaker’s honoraria from AstraZeneca and GSK; and provided consultancy for AstraZeneca, GSK, and Menarini. M. J. Abramson has undertaken an unrelated consultancy for and received assistance with conference attendance from Sanofi. He has also received a speaker’s fee from GSK. The rest of the authors declare that they have no relevant conflicts of interest.
Publisher Copyright:
© 2022 American Academy of Allergy, Asthma & Immunology
PY - 2022/9
Y1 - 2022/9
N2 - Background: The management of obstructive airway diseases (OADs) is complex. The treatable traits (TTs) approach may be an effective strategy for managing OADs. Objective: To determine the effectiveness of interventions targeting TTs for managing OADs. Methods: Ovid Embase, Medline, CENTRAL, and CINAHL Plus were searched from inception to March 9, 2022. Studies of interventions targeting at least 1 TT from pulmonary, extrapulmonary, and behavioral/lifestyle domains were included. Two reviewers independently extracted relevant data and performed risk-of-bias assessments. Meta-analyses were performed using random-effects models. Subgroup and sensitivity analyses were carried out to explore heterogeneity and to determine the effects of outlying studies. Results: Eleven studies that used the TTs approach for OAD management were identified. Traits targeted within each study ranged from 13 to 36. Seven controlled trials were included in meta-analyses. TT interventions were effective at improving health-related quality of life (mean difference [MD] = −6.96, 95% CI: −9.92 to −4.01), hospitalizations (odds ratio [OR] = 0.52, 95% CI: 0.39 to 0.69), all-cause-1-year mortality (OR = 0.65, 95% CI: 0.45 to 0.95), dyspnea score (MD = −0.29, 95% CI: −0.46 to −0.12), anxiety (MD = −1.61, 95% CI: −2.92 to −0.30), and depression (MD = −2.00, 95% CI: −3.53 to −0.47). Conclusion: Characterizing TTs and targeted interventions can improve outcomes in OADs, which offer a promising model of care for OADs.
AB - Background: The management of obstructive airway diseases (OADs) is complex. The treatable traits (TTs) approach may be an effective strategy for managing OADs. Objective: To determine the effectiveness of interventions targeting TTs for managing OADs. Methods: Ovid Embase, Medline, CENTRAL, and CINAHL Plus were searched from inception to March 9, 2022. Studies of interventions targeting at least 1 TT from pulmonary, extrapulmonary, and behavioral/lifestyle domains were included. Two reviewers independently extracted relevant data and performed risk-of-bias assessments. Meta-analyses were performed using random-effects models. Subgroup and sensitivity analyses were carried out to explore heterogeneity and to determine the effects of outlying studies. Results: Eleven studies that used the TTs approach for OAD management were identified. Traits targeted within each study ranged from 13 to 36. Seven controlled trials were included in meta-analyses. TT interventions were effective at improving health-related quality of life (mean difference [MD] = −6.96, 95% CI: −9.92 to −4.01), hospitalizations (odds ratio [OR] = 0.52, 95% CI: 0.39 to 0.69), all-cause-1-year mortality (OR = 0.65, 95% CI: 0.45 to 0.95), dyspnea score (MD = −0.29, 95% CI: −0.46 to −0.12), anxiety (MD = −1.61, 95% CI: −2.92 to −0.30), and depression (MD = −2.00, 95% CI: −3.53 to −0.47). Conclusion: Characterizing TTs and targeted interventions can improve outcomes in OADs, which offer a promising model of care for OADs.
KW - Asthma
KW - Asthma-COPD overlap
KW - Chronic obstructive pulmonary disease
KW - Meta-analysis
KW - Multidimensional assessment
KW - Obstructive airway diseases
KW - Treatable traits
UR - https://www.scopus.com/pages/publications/85132755705
U2 - 10.1016/j.jaip.2022.05.012
DO - 10.1016/j.jaip.2022.05.012
M3 - Article
C2 - 35643276
AN - SCOPUS:85132755705
SN - 2213-2198
VL - 10
SP - 2333-2345.e21
JO - Journal of Allergy and Clinical Immunology: In Practice
JF - Journal of Allergy and Clinical Immunology: In Practice
IS - 9
ER -