Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 122 - 124 |
| Number of pages | 3 |
| Journal | Journal of Chemotherapy |
| Volume | 26 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2014 |
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Effective removal of colistin methanesulphonate and formed colistin during intermittent haemodialysis in a patient infected by polymyxin-only-susceptible Pseudomonas aeruginosa. / Luque, Sonia; Sorli, Luisa; Li, Jian; Collado, Silvia; Barbosa, Francesc; Berenguer, Nuria; Horcajada, Juan Pablo; Grau, Santiago.
In: Journal of Chemotherapy, Vol. 26, No. 2, 2014, p. 122 - 124.Research output: Contribution to journal › Letter › Other
TY - JOUR
T1 - Effective removal of colistin methanesulphonate and formed colistin during intermittent haemodialysis in a patient infected by polymyxin-only-susceptible Pseudomonas aeruginosa
AU - Luque, Sonia
AU - Sorli, Luisa
AU - Li, Jian
AU - Collado, Silvia
AU - Barbosa, Francesc
AU - Berenguer, Nuria
AU - Horcajada, Juan Pablo
AU - Grau, Santiago
PY - 2014
Y1 - 2014
N2 - Colistin use has reemerged for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. However, the information on its pharmacokinetics is limited, especially in patients with end-stage renal disease, in which dosage adjustments are contradictory, and evidences the need to investigate the removal of colistin through renal replacement therapies like haemodialysis. This case study showed efficient removal of colistin methanesulphonate and formed colistin during intermittent haemodialysis in a patient infected by polymyxin-only-susceptible Pseudomonas aeruginosa. These results suggest the importance to monitor colistin plasma concentrations in these patients to minimize treatment failure due to suboptimal exposure to antibacterial colistin.
AB - Colistin use has reemerged for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. However, the information on its pharmacokinetics is limited, especially in patients with end-stage renal disease, in which dosage adjustments are contradictory, and evidences the need to investigate the removal of colistin through renal replacement therapies like haemodialysis. This case study showed efficient removal of colistin methanesulphonate and formed colistin during intermittent haemodialysis in a patient infected by polymyxin-only-susceptible Pseudomonas aeruginosa. These results suggest the importance to monitor colistin plasma concentrations in these patients to minimize treatment failure due to suboptimal exposure to antibacterial colistin.
U2 - 10.1179/1973947813Y.0000000104
DO - 10.1179/1973947813Y.0000000104
M3 - Letter
VL - 26
SP - 122
EP - 124
JO - Journal of Chemotherapy
JF - Journal of Chemotherapy
SN - 1120-009X
IS - 2
ER -