Effective removal of colistin methanesulphonate and formed colistin during intermittent haemodialysis in a patient infected by polymyxin-only-susceptible Pseudomonas aeruginosa

Sonia Luque, Luisa Sorli, Jian Li, Silvia Collado, Francesc Barbosa, Nuria Berenguer, Juan Pablo Horcajada, Santiago Grau

Research output: Contribution to journalLetterOther

10 Citations (Scopus)

Abstract

Colistin use has reemerged for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. However, the information on its pharmacokinetics is limited, especially in patients with end-stage renal disease, in which dosage adjustments are contradictory, and evidences the need to investigate the removal of colistin through renal replacement therapies like haemodialysis. This case study showed efficient removal of colistin methanesulphonate and formed colistin during intermittent haemodialysis in a patient infected by polymyxin-only-susceptible Pseudomonas aeruginosa. These results suggest the importance to monitor colistin plasma concentrations in these patients to minimize treatment failure due to suboptimal exposure to antibacterial colistin.
Original languageEnglish
Pages (from-to)122 - 124
Number of pages3
JournalJournal of Chemotherapy
Volume26
Issue number2
DOIs
Publication statusPublished - 2014

Cite this

Luque, Sonia ; Sorli, Luisa ; Li, Jian ; Collado, Silvia ; Barbosa, Francesc ; Berenguer, Nuria ; Horcajada, Juan Pablo ; Grau, Santiago. / Effective removal of colistin methanesulphonate and formed colistin during intermittent haemodialysis in a patient infected by polymyxin-only-susceptible Pseudomonas aeruginosa. In: Journal of Chemotherapy. 2014 ; Vol. 26, No. 2. pp. 122 - 124.
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abstract = "Colistin use has reemerged for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. However, the information on its pharmacokinetics is limited, especially in patients with end-stage renal disease, in which dosage adjustments are contradictory, and evidences the need to investigate the removal of colistin through renal replacement therapies like haemodialysis. This case study showed efficient removal of colistin methanesulphonate and formed colistin during intermittent haemodialysis in a patient infected by polymyxin-only-susceptible Pseudomonas aeruginosa. These results suggest the importance to monitor colistin plasma concentrations in these patients to minimize treatment failure due to suboptimal exposure to antibacterial colistin.",
author = "Sonia Luque and Luisa Sorli and Jian Li and Silvia Collado and Francesc Barbosa and Nuria Berenguer and Horcajada, {Juan Pablo} and Santiago Grau",
year = "2014",
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Effective removal of colistin methanesulphonate and formed colistin during intermittent haemodialysis in a patient infected by polymyxin-only-susceptible Pseudomonas aeruginosa. / Luque, Sonia; Sorli, Luisa; Li, Jian; Collado, Silvia; Barbosa, Francesc; Berenguer, Nuria; Horcajada, Juan Pablo; Grau, Santiago.

In: Journal of Chemotherapy, Vol. 26, No. 2, 2014, p. 122 - 124.

Research output: Contribution to journalLetterOther

TY - JOUR

T1 - Effective removal of colistin methanesulphonate and formed colistin during intermittent haemodialysis in a patient infected by polymyxin-only-susceptible Pseudomonas aeruginosa

AU - Luque, Sonia

AU - Sorli, Luisa

AU - Li, Jian

AU - Collado, Silvia

AU - Barbosa, Francesc

AU - Berenguer, Nuria

AU - Horcajada, Juan Pablo

AU - Grau, Santiago

PY - 2014

Y1 - 2014

N2 - Colistin use has reemerged for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. However, the information on its pharmacokinetics is limited, especially in patients with end-stage renal disease, in which dosage adjustments are contradictory, and evidences the need to investigate the removal of colistin through renal replacement therapies like haemodialysis. This case study showed efficient removal of colistin methanesulphonate and formed colistin during intermittent haemodialysis in a patient infected by polymyxin-only-susceptible Pseudomonas aeruginosa. These results suggest the importance to monitor colistin plasma concentrations in these patients to minimize treatment failure due to suboptimal exposure to antibacterial colistin.

AB - Colistin use has reemerged for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. However, the information on its pharmacokinetics is limited, especially in patients with end-stage renal disease, in which dosage adjustments are contradictory, and evidences the need to investigate the removal of colistin through renal replacement therapies like haemodialysis. This case study showed efficient removal of colistin methanesulphonate and formed colistin during intermittent haemodialysis in a patient infected by polymyxin-only-susceptible Pseudomonas aeruginosa. These results suggest the importance to monitor colistin plasma concentrations in these patients to minimize treatment failure due to suboptimal exposure to antibacterial colistin.

U2 - 10.1179/1973947813Y.0000000104

DO - 10.1179/1973947813Y.0000000104

M3 - Letter

VL - 26

SP - 122

EP - 124

JO - Journal of Chemotherapy

JF - Journal of Chemotherapy

SN - 1120-009X

IS - 2

ER -