Effective angiogenesis requires regulation of phosphoinositide signaling

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Abstract

Phosphoinositide signaling regulates numerous downstream effectors that mediate cellular processes which influence cell cycle progression, migration, proliferation, growth, survival, metabolism and vesicular trafficking. A prominent role for phosphoinositide 3-kinase, which generates phosphatidylinositol 3,4,5-trisphosphate, a phospholipid that activates a plethora of effectors including AKT and FOXO during embryonic and postnatal angiogenesis, has been described. In addition, phosphatidylinositol 3-phosphate signaling is required for endosomal trafficking, which contributes to vascular remodeling. This review will examine the role phosphoinositide signaling plays in the endothelium and its contribution to sprouting angiogenesis.

Original languageEnglish
Pages (from-to)69-78
Number of pages10
JournalAdvances in Biological Regulation
Volume71
DOIs
Publication statusPublished - Jan 2019

Keywords

  • Angiogenesis
  • Phosphoinositide
  • PI3K
  • PTEN

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