Effect of valsartan on the incidence of diabetes and cardiovascular events

John McMurray; R Holman; Steven Haffner; M Bethel; Bjoern Holzhauer; Tsushung Hua; Yuri Belenkov; Mitradev Boolell; John Buse; Brendan Buckley; Antonio Chacra; Fu-Tien Chiang; Bernard Charbonnel; Chun-Chung Chow; Melanie Davies; Prakash Deedwania; Peter Diem; Daniel Einhorn; Vivian Fonseca; Gregory Fulcher; Zbigniew Gaciong; Sonia Gaztambide; Thomas Giles; Edward Horton; Hasan Ilkova; Trond Jenssen; Steven Kahn; Henry Krum; Markku Laakso; Lawrence Leiter; Naomi Levitt; Viacheslav Mareev; Felipe Martinez; Chantal Masson; Theodore Mazzone; Eduardo Meaney; Richard Nesto; Changyu Pan; Rudolf Prager; Sotirios Raptis; Guy Rutten; Herbert Sandstroem; Frank Schaper; Andre Scheen; Ole Schmitz; Isaac Sinay; Vladimir Soska; Steen Stender; Gyula Tamas; Gianni Tognoni; Jaakko Tuomilehto; Alberto Villamil; Juraj Vozar; Robert Califf

doi:10.1056/NEJMoa1001121

Effect of valsartan on the incidence of diabetes and cardiovascular events

John McMurray, R Holman, Steven Haffner, M Bethel, Bjoern Holzhauer, Tsushung Hua, Yuri Belenkov, Mitradev Boolell, John Buse, Brendan Buckley, Antonio Chacra, Fu-Tien Chiang, Bernard Charbonnel, Chun-Chung Chow, Melanie Davies, Prakash Deedwania, Peter Diem, Daniel Einhorn, Vivian Fonseca, Gregory FulcherZbigniew Gaciong, Sonia Gaztambide, Thomas Giles, Edward Horton, Hasan Ilkova, Trond Jenssen, Steven Kahn, Henry Krum, Markku Laakso, Lawrence Leiter, Naomi Levitt, Viacheslav Mareev, Felipe Martinez, Chantal Masson, Theodore Mazzone, Eduardo Meaney, Richard Nesto, Changyu Pan, Rudolf Prager, Sotirios Raptis, Guy Rutten, Herbert Sandstroem, Frank Schaper, Andre Scheen, Ole Schmitz, Isaac Sinay, Vladimir Soska, Steen Stender, Gyula Tamas, Gianni Tognoni, Jaakko Tuomilehto, Alberto Villamil, Juraj Vozar, Robert Califf

Epidemiology and Preventive Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

467 Citations (Scopus)

Abstract

In this double-blind, randomized clinical trial with a 2-by-2 factorial design, we assigned 9306 patients with impaired glucose tolerance and established cardiovascular disease or cardiovascular risk factors to receive valsartan (up to 160 mg daily) or placebo (and nateglinide or placebo) in addition to lifestyle modification

Original language	English
Pages (from-to)	1477 - 1490
Number of pages	14
Journal	The New England Journal of Medicine
Volume	362
DOIs	https://doi.org/10.1056/NEJMoa1001121
Publication status	Published - 2010

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McMurray, J., Holman, R., Haffner, S., Bethel, M., Holzhauer, B., Hua, T., Belenkov, Y., Boolell, M., Buse, J., Buckley, B., Chacra, A., Chiang, F-T., Charbonnel, B., Chow, C-C., Davies, M., Deedwania, P., Diem, P., Einhorn, D., Fonseca, V., ... Califf, R. (2010). Effect of valsartan on the incidence of diabetes and cardiovascular events. The New England Journal of Medicine, 362, 1477 - 1490. https://doi.org/10.1056/NEJMoa1001121

McMurray, John ; Holman, R ; Haffner, Steven ; Bethel, M ; Holzhauer, Bjoern ; Hua, Tsushung ; Belenkov, Yuri ; Boolell, Mitradev ; Buse, John ; Buckley, Brendan ; Chacra, Antonio ; Chiang, Fu-Tien ; Charbonnel, Bernard ; Chow, Chun-Chung ; Davies, Melanie ; Deedwania, Prakash ; Diem, Peter ; Einhorn, Daniel ; Fonseca, Vivian ; Fulcher, Gregory ; Gaciong, Zbigniew ; Gaztambide, Sonia ; Giles, Thomas ; Horton, Edward ; Ilkova, Hasan ; Jenssen, Trond ; Kahn, Steven ; Krum, Henry ; Laakso, Markku ; Leiter, Lawrence ; Levitt, Naomi ; Mareev, Viacheslav ; Martinez, Felipe ; Masson, Chantal ; Mazzone, Theodore ; Meaney, Eduardo ; Nesto, Richard ; Pan, Changyu ; Prager, Rudolf ; Raptis, Sotirios ; Rutten, Guy ; Sandstroem, Herbert ; Schaper, Frank ; Scheen, Andre ; Schmitz, Ole ; Sinay, Isaac ; Soska, Vladimir ; Stender, Steen ; Tamas, Gyula ; Tognoni, Gianni ; Tuomilehto, Jaakko ; Villamil, Alberto ; Vozar, Juraj ; Califf, Robert. / Effect of valsartan on the incidence of diabetes and cardiovascular events. In: The New England Journal of Medicine. 2010 ; Vol. 362. pp. 1477 - 1490.

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title = "Effect of valsartan on the incidence of diabetes and cardiovascular events",

abstract = "In this double-blind, randomized clinical trial with a 2-by-2 factorial design, we assigned 9306 patients with impaired glucose tolerance and established cardiovascular disease or cardiovascular risk factors to receive valsartan (up to 160 mg daily) or placebo (and nateglinide or placebo) in addition to lifestyle modification",

author = "John McMurray and R Holman and Steven Haffner and M Bethel and Bjoern Holzhauer and Tsushung Hua and Yuri Belenkov and Mitradev Boolell and John Buse and Brendan Buckley and Antonio Chacra and Fu-Tien Chiang and Bernard Charbonnel and Chun-Chung Chow and Melanie Davies and Prakash Deedwania and Peter Diem and Daniel Einhorn and Vivian Fonseca and Gregory Fulcher and Zbigniew Gaciong and Sonia Gaztambide and Thomas Giles and Edward Horton and Hasan Ilkova and Trond Jenssen and Steven Kahn and Henry Krum and Markku Laakso and Lawrence Leiter and Naomi Levitt and Viacheslav Mareev and Felipe Martinez and Chantal Masson and Theodore Mazzone and Eduardo Meaney and Richard Nesto and Changyu Pan and Rudolf Prager and Sotirios Raptis and Guy Rutten and Herbert Sandstroem and Frank Schaper and Andre Scheen and Ole Schmitz and Isaac Sinay and Vladimir Soska and Steen Stender and Gyula Tamas and Gianni Tognoni and Jaakko Tuomilehto and Alberto Villamil and Juraj Vozar and Robert Califf",

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doi = "10.1056/NEJMoa1001121",

language = "English",

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McMurray, J, Holman, R, Haffner, S, Bethel, M, Holzhauer, B, Hua, T, Belenkov, Y, Boolell, M, Buse, J, Buckley, B, Chacra, A, Chiang, F-T, Charbonnel, B, Chow, C-C, Davies, M, Deedwania, P, Diem, P, Einhorn, D, Fonseca, V, Fulcher, G, Gaciong, Z, Gaztambide, S, Giles, T, Horton, E, Ilkova, H, Jenssen, T, Kahn, S, Krum, H, Laakso, M, Leiter, L, Levitt, N, Mareev, V, Martinez, F, Masson, C, Mazzone, T, Meaney, E, Nesto, R, Pan, C, Prager, R, Raptis, S, Rutten, G, Sandstroem, H, Schaper, F, Scheen, A, Schmitz, O, Sinay, I, Soska, V, Stender, S, Tamas, G, Tognoni, G, Tuomilehto, J, Villamil, A, Vozar, J & Califf, R 2010, 'Effect of valsartan on the incidence of diabetes and cardiovascular events', The New England Journal of Medicine, vol. 362, pp. 1477 - 1490. https://doi.org/10.1056/NEJMoa1001121

Effect of valsartan on the incidence of diabetes and cardiovascular events. / McMurray, John; Holman, R; Haffner, Steven; Bethel, M; Holzhauer, Bjoern; Hua, Tsushung; Belenkov, Yuri; Boolell, Mitradev; Buse, John; Buckley, Brendan; Chacra, Antonio; Chiang, Fu-Tien; Charbonnel, Bernard; Chow, Chun-Chung; Davies, Melanie; Deedwania, Prakash; Diem, Peter; Einhorn, Daniel; Fonseca, Vivian; Fulcher, Gregory; Gaciong, Zbigniew; Gaztambide, Sonia; Giles, Thomas; Horton, Edward; Ilkova, Hasan; Jenssen, Trond; Kahn, Steven; Krum, Henry; Laakso, Markku; Leiter, Lawrence; Levitt, Naomi; Mareev, Viacheslav; Martinez, Felipe; Masson, Chantal; Mazzone, Theodore; Meaney, Eduardo; Nesto, Richard; Pan, Changyu; Prager, Rudolf; Raptis, Sotirios; Rutten, Guy; Sandstroem, Herbert; Schaper, Frank; Scheen, Andre; Schmitz, Ole; Sinay, Isaac; Soska, Vladimir; Stender, Steen; Tamas, Gyula; Tognoni, Gianni; Tuomilehto, Jaakko; Villamil, Alberto; Vozar, Juraj; Califf, Robert.

In: The New England Journal of Medicine, Vol. 362, 2010, p. 1477 - 1490.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Belenkov, Yuri

AU - Boolell, Mitradev

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AU - Buckley, Brendan

AU - Chacra, Antonio

AU - Chiang, Fu-Tien

AU - Charbonnel, Bernard

AU - Chow, Chun-Chung

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AU - Deedwania, Prakash

AU - Diem, Peter

AU - Einhorn, Daniel

AU - Fonseca, Vivian

AU - Fulcher, Gregory

AU - Gaciong, Zbigniew

AU - Gaztambide, Sonia

AU - Giles, Thomas

AU - Horton, Edward

AU - Ilkova, Hasan

AU - Jenssen, Trond

AU - Kahn, Steven

AU - Krum, Henry

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AU - Mareev, Viacheslav

AU - Martinez, Felipe

AU - Masson, Chantal

AU - Mazzone, Theodore

AU - Meaney, Eduardo

AU - Nesto, Richard

AU - Pan, Changyu

AU - Prager, Rudolf

AU - Raptis, Sotirios

AU - Rutten, Guy

AU - Sandstroem, Herbert

AU - Schaper, Frank

AU - Scheen, Andre

AU - Schmitz, Ole

AU - Sinay, Isaac

AU - Soska, Vladimir

AU - Stender, Steen

AU - Tamas, Gyula

AU - Tognoni, Gianni

AU - Tuomilehto, Jaakko

AU - Villamil, Alberto

AU - Vozar, Juraj

AU - Califf, Robert

PY - 2010

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AB - In this double-blind, randomized clinical trial with a 2-by-2 factorial design, we assigned 9306 patients with impaired glucose tolerance and established cardiovascular disease or cardiovascular risk factors to receive valsartan (up to 160 mg daily) or placebo (and nateglinide or placebo) in addition to lifestyle modification

UR - http://www.nejm.org/doi/pdf/10.1056/NEJMoa1001121

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DO - 10.1056/NEJMoa1001121

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JO - The New England Journal of Medicine

JF - The New England Journal of Medicine

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