Effect of Treatment of Dairy Cows with Slow-Release Bovine Somatotropin During the Periparturient Period on Minerals in Plasma and Milk and on Parathyroid Hormone-Related Protein in Milk

F. M.K. Law, D. D. Leaver, T. J. Martin, K. Selleck, I. J. Clarke, P. J. Moate

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Slow-release bST was given to dairy cows as a single injection prior to calving to determine whether such treatment prevented parturient hypocalcemia or modified the concentrations of Ca and parathyroid hormone-related protein in milk during the periparturient period. Cows were treated about 1 wk prepartum, and serial blood and milk samples were taken from these and similar prepartum control cows over a 3-wk period. Plasma growth hormone concentrations in the bST-treated group reached a peak 2 d after administration and then declined linearly to control concentrations over a 14-d period. Plasma Ca was unaffected by bST treatment 1 d prior to parturition, on the day of parturition, and at 1 and 6 to 9 d postpartum. Plasma P was higher, and plasma Mg was lower, in the bST-treated group on the day of parturition and 1 d postpartum. Concentrations of Ca, P, Mg, and protein in milk were lower in bST-treated cows than in controls at parturition. Milk production of the bST-treated and control groups was similar when measured at d 6 to 9 postpartum. Concentrations of parathyroid hormone-related protein in milk were substantial at parturition and remained high thereafter, although at parturition the concentration in the milk of the bST-treated group was lower than that of the control group.

Original languageEnglish
Pages (from-to)2242-2248
Number of pages7
JournalJournal of Dairy Science
Issue number8
Publication statusPublished - 1 Jan 1994
Externally publishedYes


  • dairy cows
  • GH
  • growth hormone
  • parathyroid hormone-related protein
  • parturient hypocalcemia
  • PTHrP
  • somatotropin

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