Abstract
The effects of tocotrienols on hepatocarcinogenesis in rats fed with 2-acetylaminofluorene (AAF) were followed morphologically and histologically for a period of 20 wk. No differences between treated and control rats in the morphology and histology of their livers was observed. Cell damage was extensive in the livers of AAF-treated rats but less extensive in the AAF-tocotrienols-treated rats when compared with normal and tocotrienols-treated rats. 2-Acetylaminofluorene significantly increases the activities of both plasma and liver microsomal γ-glutamyltranspeptidase (GGT) and liver microsomal UDP-glucuronyltransferase (UDP-GT). Tocotrienols administered together with AAF significantly decrease the activities of plasma GGT after 12 and 20 wk (P < 0.01, P < 0.002, respectively) and liver microsomal UDP-GT after 20 wk (P < 0.02) when compared with the controls and with rats treated only with tocotrienols. Liver microsomal GGT also showed a similar pattern to liver microsomal UDP-GT but the decrease was not significant. These results suggest that tocotrienols administered to AAF-treated rats reduce the severity of hepatocarcinogenesis.
Original language | English |
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Pages (from-to) | 1076S-1081S |
Number of pages | 6 |
Journal | The American Journal of Clinical Nutrition |
Volume | 53 |
Issue number | 4 SUPPL. |
DOIs | |
Publication status | Published - 1991 |
Externally published | Yes |
Keywords
- 2-Acetylaminofluorene
- Carcinogenesis
- Tocotrienols
- UDP-glucuronyltransferase
- Vitamin E
- γ-Glutamyltranspeptidase