Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene

Nor Aripin Shamaan; Wan Zurinah Wan Ngah; Rusli Ibrahim; Zanariah Jarien; Abdul Gapor Md Top; Khalid Abdul Kadir

doi:10.1016/0006-2952(93)90052-X

Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene

Nor Aripin Shamaan, Wan Zurinah Wan Ngah, Rusli Ibrahim, Zanariah Jarien, Abdul Gapor Md Top, Khalid Abdul Kadir

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Abstract

The effect of tocotrienol on the activities of glutathione S-transferases (GSTs), glutathione reductase (GR) and glutathione peroxidase (GPx) in rats given 2-acetylaminofluorene (AAF) was investigated over a 20 week period. Liver and kidney GST and liver GR activities were significantly increased after AAF administration. Kidney GPx activities were significantly affected; activity assayed with cumene hydroperoxide (cu-OOH) was increased but activity assayed with H₂O₂ was reduced. Supplementation of the diet with tocotrienol in the AAF-treated rats reduced the increase in enzyme activities. Tocotrienol on its own had no effect on the enzyme activities.

Original language	English
Pages (from-to)	1517-1519
Number of pages	3
Journal	Biochemical Pharmacology
Volume	45
Issue number	7
DOIs	https://doi.org/10.1016/0006-2952(93)90052-X
Publication status	Published - 6 Apr 1993
Externally published	Yes

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title = "Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene",

abstract = "The effect of tocotrienol on the activities of glutathione S-transferases (GSTs), glutathione reductase (GR) and glutathione peroxidase (GPx) in rats given 2-acetylaminofluorene (AAF) was investigated over a 20 week period. Liver and kidney GST and liver GR activities were significantly increased after AAF administration. Kidney GPx activities were significantly affected; activity assayed with cumene hydroperoxide (cu-OOH) was increased but activity assayed with H2O2 was reduced. Supplementation of the diet with tocotrienol in the AAF-treated rats reduced the increase in enzyme activities. Tocotrienol on its own had no effect on the enzyme activities.",

author = "Shamaan, \{Nor Aripin\} and \{Wan Ngah\}, \{Wan Zurinah\} and Rusli Ibrahim and Zanariah Jarien and \{Md Top\}, \{Abdul Gapor\} and Kadir, \{Khalid Abdul\}",

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language = "English",

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T1 - Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene

AU - Shamaan, Nor Aripin

AU - Wan Ngah, Wan Zurinah

AU - Ibrahim, Rusli

AU - Jarien, Zanariah

AU - Md Top, Abdul Gapor

AU - Kadir, Khalid Abdul

PY - 1993/4/6

Y1 - 1993/4/6

N2 - The effect of tocotrienol on the activities of glutathione S-transferases (GSTs), glutathione reductase (GR) and glutathione peroxidase (GPx) in rats given 2-acetylaminofluorene (AAF) was investigated over a 20 week period. Liver and kidney GST and liver GR activities were significantly increased after AAF administration. Kidney GPx activities were significantly affected; activity assayed with cumene hydroperoxide (cu-OOH) was increased but activity assayed with H2O2 was reduced. Supplementation of the diet with tocotrienol in the AAF-treated rats reduced the increase in enzyme activities. Tocotrienol on its own had no effect on the enzyme activities.

AB - The effect of tocotrienol on the activities of glutathione S-transferases (GSTs), glutathione reductase (GR) and glutathione peroxidase (GPx) in rats given 2-acetylaminofluorene (AAF) was investigated over a 20 week period. Liver and kidney GST and liver GR activities were significantly increased after AAF administration. Kidney GPx activities were significantly affected; activity assayed with cumene hydroperoxide (cu-OOH) was increased but activity assayed with H2O2 was reduced. Supplementation of the diet with tocotrienol in the AAF-treated rats reduced the increase in enzyme activities. Tocotrienol on its own had no effect on the enzyme activities.

UR - https://www.scopus.com/pages/publications/0027535269

U2 - 10.1016/0006-2952(93)90052-X

DO - 10.1016/0006-2952(93)90052-X

M3 - Article

C2 - 8471073

AN - SCOPUS:0027535269

SN - 0006-2952

VL - 45

SP - 1517

EP - 1519

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

IS - 7

ER -

Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene

Abstract

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