Abstract
The effect of tocotrienol on the activities of glutathione S-transferases (GSTs), glutathione reductase (GR) and glutathione peroxidase (GPx) in rats given 2-acetylaminofluorene (AAF) was investigated over a 20 week period. Liver and kidney GST and liver GR activities were significantly increased after AAF administration. Kidney GPx activities were significantly affected; activity assayed with cumene hydroperoxide (cu-OOH) was increased but activity assayed with H2O2 was reduced. Supplementation of the diet with tocotrienol in the AAF-treated rats reduced the increase in enzyme activities. Tocotrienol on its own had no effect on the enzyme activities.
Original language | English |
---|---|
Pages (from-to) | 1517-1519 |
Number of pages | 3 |
Journal | Biochemical Pharmacology |
Volume | 45 |
Issue number | 7 |
DOIs | |
Publication status | Published - 6 Apr 1993 |
Externally published | Yes |