Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene

Nor Aripin Shamaan, Wan Zurinah Wan Ngah, Rusli Ibrahim, Zanariah Jarien, Abdul Gapor Md Top, Khalid Abdul Kadir

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The effect of tocotrienol on the activities of glutathione S-transferases (GSTs), glutathione reductase (GR) and glutathione peroxidase (GPx) in rats given 2-acetylaminofluorene (AAF) was investigated over a 20 week period. Liver and kidney GST and liver GR activities were significantly increased after AAF administration. Kidney GPx activities were significantly affected; activity assayed with cumene hydroperoxide (cu-OOH) was increased but activity assayed with H2O2 was reduced. Supplementation of the diet with tocotrienol in the AAF-treated rats reduced the increase in enzyme activities. Tocotrienol on its own had no effect on the enzyme activities.

Original languageEnglish
Pages (from-to)1517-1519
Number of pages3
JournalBiochemical Pharmacology
Issue number7
Publication statusPublished - 6 Apr 1993
Externally publishedYes

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