Effect of the dopamine D 3 receptor antagonist GSK598809 on brain responses to rewarding food images in overweight and obese binge eaters

Chris Martin Dodds, Barry O'Neill, John Beaver, Aidan Makwana, Massimo Bani, Emilio V Merlo-Pich, Paul C Fletcher, Annelize Koch, Edward T. Bullmore, Pradeep J. Nathan

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29 Citations (Scopus)

Abstract

The dopamine D 3 receptor is thought to be a potential target for treating compulsive disorders such as drug addiction and obesity. Here, we used functional Magnetic Resonance Imaging (fMRI) to investigate the effects the selective dopamine D 3 receptor antagonist GSK598809 on brain activation to food images in a sample of overweight and obese binge-eating subjects. Consistent with previous studies, processing of food images was associated with activation of a network of reward areas including the amygdala, striatum and insula. However, brain activation to food images was not modulated by GSK598809. The results demonstrate that D 3 receptor manipulation does not modulate brain responses to food images in overweight and obese subjects.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalAppetite
Volume59
Issue number1
DOIs
Publication statusPublished - Aug 2012
Externally publishedYes

Keywords

  • D receptor
  • Dopamine
  • Food images
  • Obesity
  • Reward circuitry

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