Effect of the deformability of guest particles on the tensile strength of tablets from interactive mixtures

Sharad Mangal, Satu Lakio, Thomas Gengenbach, Ian Larson, David A.V. Morton

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

In this study, we investigated the influence of deformability of specifically-engineered guest particles on the tensile strength of tablets of interactive mixtures. The binder polyvinylpyrrolidone (PVP) of different molecular weights were spray dried with L-leucine to create guest particle formulations. The guest particle formulations were characterized by their particle size, surface L-leucine concentration and glass transition temperature (Tg). These spray-dried particles were then blended with paracetamol to form interactive mixtures, which were compacted into tablets and tablet tensile strength and elastic recovery were determined. The guest particles had particle diameters in the range of 1–10 μm, and surfaces that were L-leucine enriched. The Tg of guest particle formulations increased with increasing molecular weight of the PVP. All the guest particle formulations formed an observed homogeneous interactive mixture with paracetamol. The tensile strength of the tablets of interactive mixtures increased with decreasing Tg of the guest particles. In these interactive mixtures, higher tensile strength was also associated with lower tablet elastic recovery. The elastic recovery of the tablets showed a correlation with the elastic recovery of the tablets of guest particles. Thus, our results indicated that the deformability of guest particles dictates the tensile strength of the tablets of these interactive mixtures.

Original languageEnglish
Pages (from-to)341-352
Number of pages12
JournalInternational Journal of Pharmaceutics
Volume514
Issue number2
DOIs
Publication statusPublished - 5 Dec 2016

Keywords

  • Binder
  • Elasticity
  • Host particles
  • Interactive mixing
  • L-Leucine
  • Paracetamol
  • Polyvinylpyrrolidone
  • Spray drying
  • Tabletting

Cite this

Mangal, Sharad ; Lakio, Satu ; Gengenbach, Thomas ; Larson, Ian ; Morton, David A.V. / Effect of the deformability of guest particles on the tensile strength of tablets from interactive mixtures. In: International Journal of Pharmaceutics. 2016 ; Vol. 514, No. 2. pp. 341-352.
@article{80de0bfb38d0435d8de7ce581b2fb6df,
title = "Effect of the deformability of guest particles on the tensile strength of tablets from interactive mixtures",
abstract = "In this study, we investigated the influence of deformability of specifically-engineered guest particles on the tensile strength of tablets of interactive mixtures. The binder polyvinylpyrrolidone (PVP) of different molecular weights were spray dried with L-leucine to create guest particle formulations. The guest particle formulations were characterized by their particle size, surface L-leucine concentration and glass transition temperature (Tg). These spray-dried particles were then blended with paracetamol to form interactive mixtures, which were compacted into tablets and tablet tensile strength and elastic recovery were determined. The guest particles had particle diameters in the range of 1–10 μm, and surfaces that were L-leucine enriched. The Tg of guest particle formulations increased with increasing molecular weight of the PVP. All the guest particle formulations formed an observed homogeneous interactive mixture with paracetamol. The tensile strength of the tablets of interactive mixtures increased with decreasing Tg of the guest particles. In these interactive mixtures, higher tensile strength was also associated with lower tablet elastic recovery. The elastic recovery of the tablets showed a correlation with the elastic recovery of the tablets of guest particles. Thus, our results indicated that the deformability of guest particles dictates the tensile strength of the tablets of these interactive mixtures.",
keywords = "Binder, Elasticity, Host particles, Interactive mixing, L-Leucine, Paracetamol, Polyvinylpyrrolidone, Spray drying, Tabletting",
author = "Sharad Mangal and Satu Lakio and Thomas Gengenbach and Ian Larson and Morton, {David A.V.}",
year = "2016",
month = "12",
day = "5",
doi = "10.1016/j.ijpharm.2016.03.038",
language = "English",
volume = "514",
pages = "341--352",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "2",

}

Effect of the deformability of guest particles on the tensile strength of tablets from interactive mixtures. / Mangal, Sharad; Lakio, Satu; Gengenbach, Thomas; Larson, Ian; Morton, David A.V.

In: International Journal of Pharmaceutics, Vol. 514, No. 2, 05.12.2016, p. 341-352.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Effect of the deformability of guest particles on the tensile strength of tablets from interactive mixtures

AU - Mangal, Sharad

AU - Lakio, Satu

AU - Gengenbach, Thomas

AU - Larson, Ian

AU - Morton, David A.V.

PY - 2016/12/5

Y1 - 2016/12/5

N2 - In this study, we investigated the influence of deformability of specifically-engineered guest particles on the tensile strength of tablets of interactive mixtures. The binder polyvinylpyrrolidone (PVP) of different molecular weights were spray dried with L-leucine to create guest particle formulations. The guest particle formulations were characterized by their particle size, surface L-leucine concentration and glass transition temperature (Tg). These spray-dried particles were then blended with paracetamol to form interactive mixtures, which were compacted into tablets and tablet tensile strength and elastic recovery were determined. The guest particles had particle diameters in the range of 1–10 μm, and surfaces that were L-leucine enriched. The Tg of guest particle formulations increased with increasing molecular weight of the PVP. All the guest particle formulations formed an observed homogeneous interactive mixture with paracetamol. The tensile strength of the tablets of interactive mixtures increased with decreasing Tg of the guest particles. In these interactive mixtures, higher tensile strength was also associated with lower tablet elastic recovery. The elastic recovery of the tablets showed a correlation with the elastic recovery of the tablets of guest particles. Thus, our results indicated that the deformability of guest particles dictates the tensile strength of the tablets of these interactive mixtures.

AB - In this study, we investigated the influence of deformability of specifically-engineered guest particles on the tensile strength of tablets of interactive mixtures. The binder polyvinylpyrrolidone (PVP) of different molecular weights were spray dried with L-leucine to create guest particle formulations. The guest particle formulations were characterized by their particle size, surface L-leucine concentration and glass transition temperature (Tg). These spray-dried particles were then blended with paracetamol to form interactive mixtures, which were compacted into tablets and tablet tensile strength and elastic recovery were determined. The guest particles had particle diameters in the range of 1–10 μm, and surfaces that were L-leucine enriched. The Tg of guest particle formulations increased with increasing molecular weight of the PVP. All the guest particle formulations formed an observed homogeneous interactive mixture with paracetamol. The tensile strength of the tablets of interactive mixtures increased with decreasing Tg of the guest particles. In these interactive mixtures, higher tensile strength was also associated with lower tablet elastic recovery. The elastic recovery of the tablets showed a correlation with the elastic recovery of the tablets of guest particles. Thus, our results indicated that the deformability of guest particles dictates the tensile strength of the tablets of these interactive mixtures.

KW - Binder

KW - Elasticity

KW - Host particles

KW - Interactive mixing

KW - L-Leucine

KW - Paracetamol

KW - Polyvinylpyrrolidone

KW - Spray drying

KW - Tabletting

UR - http://www.scopus.com/inward/record.url?scp=84975503208&partnerID=8YFLogxK

U2 - 10.1016/j.ijpharm.2016.03.038

DO - 10.1016/j.ijpharm.2016.03.038

M3 - Article

AN - SCOPUS:84975503208

VL - 514

SP - 341

EP - 352

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 2

ER -