Effect of renal sympathetic denervation on glucose metabolism in patients with resistant hypertension: A pilot study

Felix Mahfoud, Markus Schlaich, Ingrid Kindermann, Christian Ukena, Bodo Cremers, Mathias Brandt, Uta Hoppe, Oliver Vonend, Lars Rump, Paul Sobotka, Henry Krum, Murray Esler, Michael Bohm

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Abstract

Methods and Results We enrolled 50 patients with therapy-resistant hypertension. Thirty-seven patients underwent bilateral catheter-based renal denervation, and 13 patients were assigned to a control group. Systolic and diastolic blood pressures, fasting glucose, insulin, C peptide, hemoglobin A1c, calculated insulin sensitivity (homeostasis model assessmenta??insulin resistance), and glucose levels during oral glucose tolerance test were measured before and 1 and 3 months after treatment. Mean office blood pressure at baseline was 178/96A?3/2 mm Hg. At 1 and 3 months, office blood pressure was reduced by a??28/a??10 mm Hg (P
Original languageEnglish
Pages (from-to)1940 - 1946
Number of pages7
JournalCirculation
Volume123
Issue number18
DOIs
Publication statusPublished - 2011

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