Effect of 'renal-dose' dopamine on renal function following cardiac surgery

P. S. Myles, M. R. Buckland, N. J. Schenk, G. B. Cannon, M. Langley, B. B. Davis, A. M. Weeks

Research output: Contribution to journalArticleResearchpeer-review

129 Citations (Scopus)


The efficacy of renal-dose dopamine to improve renal function or reduce renal impairment was studied in 52 patients undergoing elective coronary artery bypass surgery. The patients were prospectively randomised in a double-blind fashion to receive dopamine at 200 μg/min (group D) or placebo (group P) from induction for 24 hours. Although dopamine improved haemodynamics, there was no effect on urine output at 4 hours (D=917, P=1231 ml: P=0.066); urine output at 24 hours (D=3659, P=3304 ml: P=0.36); creatinine clearance at 0-4 hours (D=104, P=127 ml/min: P=0.27); creatinine clearance on admission to ICU-4 hours (D=94.8, P=83.4 ml/min: P=0.48); creatinine clearance at 20-24 hours (D=91.2, P=107 ml/min: P=0.48); free-water clearance at 0-4 hours (D=29.6, P=-59.8 ml/hr: P=0.069); free-water clearance at 20-24 hours (D=43.2, P=-48.9 ml/hr: P=0.55). The incidence of transient renal impairment was similar in both groups (D=36%, P=50%: P=0.65). Our study failed to demonstrate that routine prophylactic renal-dose dopamine is associated with improvement in renal function, or with prevention of transient renal impairment in patients undergoing coronary artery bypass surgery.

Original languageEnglish
Pages (from-to)56-61
Number of pages6
JournalAnaesthesia and Intensive Care
Issue number1
Publication statusPublished - 1993

Cite this