Effect of 'renal-dose' dopamine on renal function following cardiac surgery

P. S. Myles, M. R. Buckland, N. J. Schenk, G. B. Cannon, M. Langley, B. B. Davis, A. M. Weeks

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The efficacy of renal-dose dopamine to improve renal function or reduce renal impairment was studied in 52 patients undergoing elective coronary artery bypass surgery. The patients were prospectively randomised in a double-blind fashion to receive dopamine at 200 μg/min (group D) or placebo (group P) from induction for 24 hours. Although dopamine improved haemodynamics, there was no effect on urine output at 4 hours (D=917, P=1231 ml: P=0.066); urine output at 24 hours (D=3659, P=3304 ml: P=0.36); creatinine clearance at 0-4 hours (D=104, P=127 ml/min: P=0.27); creatinine clearance on admission to ICU-4 hours (D=94.8, P=83.4 ml/min: P=0.48); creatinine clearance at 20-24 hours (D=91.2, P=107 ml/min: P=0.48); free-water clearance at 0-4 hours (D=29.6, P=-59.8 ml/hr: P=0.069); free-water clearance at 20-24 hours (D=43.2, P=-48.9 ml/hr: P=0.55). The incidence of transient renal impairment was similar in both groups (D=36%, P=50%: P=0.65). Our study failed to demonstrate that routine prophylactic renal-dose dopamine is associated with improvement in renal function, or with prevention of transient renal impairment in patients undergoing coronary artery bypass surgery.

Original languageEnglish
Pages (from-to)56-61
Number of pages6
JournalAnaesthesia and intensive care
Volume21
Issue number1
Publication statusPublished - 1993

Cite this

Myles, P. S., Buckland, M. R., Schenk, N. J., Cannon, G. B., Langley, M., Davis, B. B., & Weeks, A. M. (1993). Effect of 'renal-dose' dopamine on renal function following cardiac surgery. Anaesthesia and intensive care, 21(1), 56-61.
Myles, P. S. ; Buckland, M. R. ; Schenk, N. J. ; Cannon, G. B. ; Langley, M. ; Davis, B. B. ; Weeks, A. M. / Effect of 'renal-dose' dopamine on renal function following cardiac surgery. In: Anaesthesia and intensive care. 1993 ; Vol. 21, No. 1. pp. 56-61.
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abstract = "The efficacy of renal-dose dopamine to improve renal function or reduce renal impairment was studied in 52 patients undergoing elective coronary artery bypass surgery. The patients were prospectively randomised in a double-blind fashion to receive dopamine at 200 μg/min (group D) or placebo (group P) from induction for 24 hours. Although dopamine improved haemodynamics, there was no effect on urine output at 4 hours (D=917, P=1231 ml: P=0.066); urine output at 24 hours (D=3659, P=3304 ml: P=0.36); creatinine clearance at 0-4 hours (D=104, P=127 ml/min: P=0.27); creatinine clearance on admission to ICU-4 hours (D=94.8, P=83.4 ml/min: P=0.48); creatinine clearance at 20-24 hours (D=91.2, P=107 ml/min: P=0.48); free-water clearance at 0-4 hours (D=29.6, P=-59.8 ml/hr: P=0.069); free-water clearance at 20-24 hours (D=43.2, P=-48.9 ml/hr: P=0.55). The incidence of transient renal impairment was similar in both groups (D=36{\%}, P=50{\%}: P=0.65). Our study failed to demonstrate that routine prophylactic renal-dose dopamine is associated with improvement in renal function, or with prevention of transient renal impairment in patients undergoing coronary artery bypass surgery.",
author = "Myles, {P. S.} and Buckland, {M. R.} and Schenk, {N. J.} and Cannon, {G. B.} and M. Langley and Davis, {B. B.} and Weeks, {A. M.}",
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Myles, PS, Buckland, MR, Schenk, NJ, Cannon, GB, Langley, M, Davis, BB & Weeks, AM 1993, 'Effect of 'renal-dose' dopamine on renal function following cardiac surgery' Anaesthesia and intensive care, vol. 21, no. 1, pp. 56-61.

Effect of 'renal-dose' dopamine on renal function following cardiac surgery. / Myles, P. S.; Buckland, M. R.; Schenk, N. J.; Cannon, G. B.; Langley, M.; Davis, B. B.; Weeks, A. M.

In: Anaesthesia and intensive care, Vol. 21, No. 1, 1993, p. 56-61.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Effect of 'renal-dose' dopamine on renal function following cardiac surgery

AU - Myles, P. S.

AU - Buckland, M. R.

AU - Schenk, N. J.

AU - Cannon, G. B.

AU - Langley, M.

AU - Davis, B. B.

AU - Weeks, A. M.

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N2 - The efficacy of renal-dose dopamine to improve renal function or reduce renal impairment was studied in 52 patients undergoing elective coronary artery bypass surgery. The patients were prospectively randomised in a double-blind fashion to receive dopamine at 200 μg/min (group D) or placebo (group P) from induction for 24 hours. Although dopamine improved haemodynamics, there was no effect on urine output at 4 hours (D=917, P=1231 ml: P=0.066); urine output at 24 hours (D=3659, P=3304 ml: P=0.36); creatinine clearance at 0-4 hours (D=104, P=127 ml/min: P=0.27); creatinine clearance on admission to ICU-4 hours (D=94.8, P=83.4 ml/min: P=0.48); creatinine clearance at 20-24 hours (D=91.2, P=107 ml/min: P=0.48); free-water clearance at 0-4 hours (D=29.6, P=-59.8 ml/hr: P=0.069); free-water clearance at 20-24 hours (D=43.2, P=-48.9 ml/hr: P=0.55). The incidence of transient renal impairment was similar in both groups (D=36%, P=50%: P=0.65). Our study failed to demonstrate that routine prophylactic renal-dose dopamine is associated with improvement in renal function, or with prevention of transient renal impairment in patients undergoing coronary artery bypass surgery.

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