Effect of perindopril on large artery stiffness and aortic root diameter in patients with Marfan syndrome: a randomized controlled trial

Anna Agnes Ahimastos, Anuradha Aggarwal, Kellie D'Orsa, Melissa Formosa, Anthony John White, Ravi Savarirayan, Anthony M Dart, Bronwyn A Kingwell

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162 Citations (Scopus)

Abstract

Aortic stiffness is increased in Marfan syndrome contributing to aortic dilatation and rupture, the major cause of premature death in this population. Angiotensin-converting enzyme inhibitors have been shown to reduce arterial stiffness. OBJECTIVE: To determine whether perindopril therapy reduces aortic stiffness and attenuates aortic dilatation in patients with Marfan syndrome. DESIGN, SETTING, AND PARTICIPANTS: A randomized, double-blind, placebo-controlled trial of 17 patients with Marfan syndrome (mean [SD], 33 [6] years) taking standard beta-blocker therapy, initiated in January 2004 and completed in September 2006, at Alfred Hospital Marfan Syndrome Clinic, Melbourne, Australia.
Original languageEnglish
Pages (from-to)1539 - 1547
Number of pages9
JournalJAMA
Volume298
Issue number13
DOIs
Publication statusPublished - 2007
Externally publishedYes

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