Effect of perfusion pressure on the splanchnic circulation after CPB: A pilot study

M. Lipcsey, L. Mcnicol, F. Parker, S. Poustie, G. Liu, S. Uchino, A. Kattula, R. Bellomo

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Background. The impact of different blood pressure targets is unknown for post cardiac surgery patient in the intensive care unit. We, therefore, investigated the effects of a mean arterial pressure (MAP) target of 65 or 85 mmHg on splanchnic oxygenation, metabolic function, cytokine regulation and gastric tonometry after cardiopulmonary bypass. Methods. Sixteen patients were randomized to the HLH group (high-low-high) where MAP of 85-65-85 mmHg was targeted or the LHL group where MAP 65-85-65 mmHg was targeted with norepinephrine infusion. Results. MAP targets were achieved in all patients at all timepoints (64±3, 84±4; 65±5, LHL group; vs. 84±3; 66±2; 85±5 mmHg, HLH group). At corresponding timepoints, hepatic venous saturation was 41±15%; 58±24%; 56±21% in the LHL group vs. 50±19%; 43±20%; 41±18% in the HLH group (P<0.05). No changes were observed in cardiac output, global or trans-splanchnic lactate levels and cytokine levels or in gastric tonometry CO2 . Conclusion. Achieving a MAP target of 85 mmHg by means of norepinephrine infusion after CPB appears safe for the splanchnic circulation.

Original languageEnglish
Pages (from-to)752-764
Number of pages13
JournalMinerva Anestesiologica
Issue number7
Publication statusPublished - Jul 2015
Externally publishedYes


  • Blood pressure
  • Cardiac surgical procedures
  • Cytokines
  • Intensive care unit
  • Splanchnic circulation

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