Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Yves SY Hsieh, Deni Taleski, Brendan Wilkinson, Lakshmi C Wijeyewickrema, Ty E Adams, Robert N Pike, Richard J Payne

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16 Citations (Scopus)

Abstract

Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.
Original languageEnglish
Pages (from-to)1547 - 1549
Number of pages3
JournalChemical Communications
Volume48
Issue number10
DOIs
Publication statusPublished - 2012

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