TY - JOUR
T1 - Effect of motilin receptor activation on food intake and food timing
AU - Deloose, Eveline
AU - Biesiekierski, Jessica R.
AU - Vanheel, Hanne
AU - Depoortere, Inge
AU - Tack, Jan
N1 - Funding Information:
Supported by the KU Leuven (Methusalem grant). ED, JRB, and HV are postdoctoral fellows of the Fonds voor Wetenschappelijk Onderzoek (FWO). FWO is a research funding institute supported by the Flemish government. The funders had no role in the design, implementation, analysis, or interpretation of the data. Supplemental Figure 1 is available from the “Supplementary data” link in the online posting of the article and from the same link in the online table of contents at https://academic.oup.com/ajcn/. Address correspondence to JT (e-mail: [email protected]). Received August 11, 2017. Accepted for publication November 20, 2017. First published online April 9, 2018; doi: https://doi.org/10.1093/ajcn/ nqx044.
Publisher Copyright:
© 2018 American Society for Nutrition. All rights reserved.
PY - 2018/4
Y1 - 2018/4
N2 - Background Motilin plasma concentrations are positively correlated with hunger ratings during the fasting state. Moreover, the motilin agonist erythromycin stimulates meal requests. Objectives The first aim of the study was to evaluate the effect of erythromycin on ad libitum food intake. The second aim was to study the involvement of endogenous motilin and octanoylated ghrelin on voluntary meal initiations. Design Study 1: Fourteen healthy participants were studied twice after an overnight fast. Intravenous administration of placebo (saline) or erythromycin (40 mg) was given in a double-blind randomized order. Participants had the opportunity to eat ad libitum from an excess free-choice buffet (2330 kcal) for the duration of 1 h. The primary outcome was total caloric intake. Study 2: Thirteen healthy participants were studied after an overnight fast. Baseline blood samples were collected before a breakfast (245 kcal). After a rest period of 90 min, blood samples were collected every 15 min for a duration of 5 h. During this period, volunteers could request small meal portions (164 kcal/serving) at time points of their choosing and unlimited in numbers. The primary outcome was the determination of plasma concentrations before postbreakfast spontaneous meal requests. Results Ad libitum food intake did not differ between placebo and erythromycin groups (difference compared with placebo: 79 kcal; 95% CI: -245.9, 403.97 kcal; P = 0.3). Octanoylated ghrelin concentrations before spontaneous meal requests were, on average, 36% (95% CI: 5.8%, 65.7%; P = 0.02) higher than values before breakfast, whereas motilin concentrations did not increase (6% increase: 95% CI: -5.9%, 17.2% increase; P = 0.3). Conclusions Motilin receptor stimulation during the fasting state does not affect total caloric intake nor does endogenous motilin stimulate meal requests after breakfast in the current study population. This trial was registered at www.clinicaltrials.gov as NCT03024879.
AB - Background Motilin plasma concentrations are positively correlated with hunger ratings during the fasting state. Moreover, the motilin agonist erythromycin stimulates meal requests. Objectives The first aim of the study was to evaluate the effect of erythromycin on ad libitum food intake. The second aim was to study the involvement of endogenous motilin and octanoylated ghrelin on voluntary meal initiations. Design Study 1: Fourteen healthy participants were studied twice after an overnight fast. Intravenous administration of placebo (saline) or erythromycin (40 mg) was given in a double-blind randomized order. Participants had the opportunity to eat ad libitum from an excess free-choice buffet (2330 kcal) for the duration of 1 h. The primary outcome was total caloric intake. Study 2: Thirteen healthy participants were studied after an overnight fast. Baseline blood samples were collected before a breakfast (245 kcal). After a rest period of 90 min, blood samples were collected every 15 min for a duration of 5 h. During this period, volunteers could request small meal portions (164 kcal/serving) at time points of their choosing and unlimited in numbers. The primary outcome was the determination of plasma concentrations before postbreakfast spontaneous meal requests. Results Ad libitum food intake did not differ between placebo and erythromycin groups (difference compared with placebo: 79 kcal; 95% CI: -245.9, 403.97 kcal; P = 0.3). Octanoylated ghrelin concentrations before spontaneous meal requests were, on average, 36% (95% CI: 5.8%, 65.7%; P = 0.02) higher than values before breakfast, whereas motilin concentrations did not increase (6% increase: 95% CI: -5.9%, 17.2% increase; P = 0.3). Conclusions Motilin receptor stimulation during the fasting state does not affect total caloric intake nor does endogenous motilin stimulate meal requests after breakfast in the current study population. This trial was registered at www.clinicaltrials.gov as NCT03024879.
KW - erythromycin
KW - food intake
KW - ghrelin
KW - insulin
KW - motilin
UR - http://www.scopus.com/inward/record.url?scp=85045843818&partnerID=8YFLogxK
U2 - 10.1093/ajcn/nqx044
DO - 10.1093/ajcn/nqx044
M3 - Article
C2 - 29635488
AN - SCOPUS:85045843818
SN - 0002-9165
VL - 107
SP - 537
EP - 543
JO - The American Journal of Clinical Nutrition
JF - The American Journal of Clinical Nutrition
IS - 4
ER -