Effect of macronutrient composition on meal-induced thermogenesis in adolescents with obesity

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Purpose: Manipulation of meal macronutrient may be a useful way to modulate meal-induced thermogenesis (MIT) to induce increases in energy expenditure. The objective of this study was to examine in adolescents with obesity and of healthy weight and the effect of a high protein and high carbohydrate meal on MIT. Methods: An acute cross-over study with adolescents aged 11–19 years was undertaken. Participants consumed in random order, a high 79% carbohydrate (HCHO), and a high 55% protein (HP) meal (adjusted to 25% of energy requirements). MIT and subjective appetite were assessed for 4 h postprandial and an ad libitum lunch served. Data calculated as total AUC and expressed as mean ± SEM. Results: Thirteen adolescents with obesity (mean BMI z score 2.3 ± 0.1) and 13 healthy weight (BMI z score 0.0 ± 0.2) participated. Mean MIT (% of energy intake) was greater after the HP (8.19 ± 0.709%) compared with the HCHO meal (4.36 ± 0.480%) (p < 0.001). The HP compared with the HCHO meal promoted greater fullness (12,994 ± 1208 vs 11,186 ± 1220 mm/4 h) (p = 0.016) and decreased hunger (8868 ± 1315 vs 10984 mm ± 1438 mm/4 h) (p = 0.007). These effects observed were independent of body weight. Conclusions: High protein meals can increase MIT and fullness and reduce hunger compared with high carbohydrate meals in adolescents with obesity. Future research is warranted to determine if MIT can be targeted through manipulation of dietary choices to support weight management strategies. Trial registration: This study is registered with the Australian New Zealand Clinical Trials Registry (ANZCTR). Trial ID: ACTRN12612001066875.

Original languageEnglish
Pages (from-to)2327–2333
Number of pages7
JournalEuropean Journal of Nutrition
Volume58
Issue number6
DOIs
Publication statusPublished - Sep 2019

Keywords

  • Acute feeding
  • Adolescent
  • Macronutrients
  • Meal-induced thermogenesis
  • Obesity

Cite this

@article{02482ad09b6f42aabd2e73fe796c3561,
title = "Effect of macronutrient composition on meal-induced thermogenesis in adolescents with obesity",
abstract = "Purpose: Manipulation of meal macronutrient may be a useful way to modulate meal-induced thermogenesis (MIT) to induce increases in energy expenditure. The objective of this study was to examine in adolescents with obesity and of healthy weight and the effect of a high protein and high carbohydrate meal on MIT. Methods: An acute cross-over study with adolescents aged 11–19 years was undertaken. Participants consumed in random order, a high 79{\%} carbohydrate (HCHO), and a high 55{\%} protein (HP) meal (adjusted to 25{\%} of energy requirements). MIT and subjective appetite were assessed for 4 h postprandial and an ad libitum lunch served. Data calculated as total AUC and expressed as mean ± SEM. Results: Thirteen adolescents with obesity (mean BMI z score 2.3 ± 0.1) and 13 healthy weight (BMI z score 0.0 ± 0.2) participated. Mean MIT ({\%} of energy intake) was greater after the HP (8.19 ± 0.709{\%}) compared with the HCHO meal (4.36 ± 0.480{\%}) (p < 0.001). The HP compared with the HCHO meal promoted greater fullness (12,994 ± 1208 vs 11,186 ± 1220 mm/4 h) (p = 0.016) and decreased hunger (8868 ± 1315 vs 10984 mm ± 1438 mm/4 h) (p = 0.007). These effects observed were independent of body weight. Conclusions: High protein meals can increase MIT and fullness and reduce hunger compared with high carbohydrate meals in adolescents with obesity. Future research is warranted to determine if MIT can be targeted through manipulation of dietary choices to support weight management strategies. Trial registration: This study is registered with the Australian New Zealand Clinical Trials Registry (ANZCTR). Trial ID: ACTRN12612001066875.",
keywords = "Acute feeding, Adolescent, Macronutrients, Meal-induced thermogenesis, Obesity",
author = "Kay Nguo and Huggins, {Catherine E.} and Helen Truby and Justin Brown and Bonham, {Maxine P.}",
year = "2019",
month = "9",
doi = "10.1007/s00394-018-1783-1",
language = "English",
volume = "58",
pages = "2327–2333",
journal = "European Journal of Nutrition",
issn = "1436-6207",
publisher = "Springer-Verlag London Ltd.",
number = "6",

}

TY - JOUR

T1 - Effect of macronutrient composition on meal-induced thermogenesis in adolescents with obesity

AU - Nguo, Kay

AU - Huggins, Catherine E.

AU - Truby, Helen

AU - Brown, Justin

AU - Bonham, Maxine P.

PY - 2019/9

Y1 - 2019/9

N2 - Purpose: Manipulation of meal macronutrient may be a useful way to modulate meal-induced thermogenesis (MIT) to induce increases in energy expenditure. The objective of this study was to examine in adolescents with obesity and of healthy weight and the effect of a high protein and high carbohydrate meal on MIT. Methods: An acute cross-over study with adolescents aged 11–19 years was undertaken. Participants consumed in random order, a high 79% carbohydrate (HCHO), and a high 55% protein (HP) meal (adjusted to 25% of energy requirements). MIT and subjective appetite were assessed for 4 h postprandial and an ad libitum lunch served. Data calculated as total AUC and expressed as mean ± SEM. Results: Thirteen adolescents with obesity (mean BMI z score 2.3 ± 0.1) and 13 healthy weight (BMI z score 0.0 ± 0.2) participated. Mean MIT (% of energy intake) was greater after the HP (8.19 ± 0.709%) compared with the HCHO meal (4.36 ± 0.480%) (p < 0.001). The HP compared with the HCHO meal promoted greater fullness (12,994 ± 1208 vs 11,186 ± 1220 mm/4 h) (p = 0.016) and decreased hunger (8868 ± 1315 vs 10984 mm ± 1438 mm/4 h) (p = 0.007). These effects observed were independent of body weight. Conclusions: High protein meals can increase MIT and fullness and reduce hunger compared with high carbohydrate meals in adolescents with obesity. Future research is warranted to determine if MIT can be targeted through manipulation of dietary choices to support weight management strategies. Trial registration: This study is registered with the Australian New Zealand Clinical Trials Registry (ANZCTR). Trial ID: ACTRN12612001066875.

AB - Purpose: Manipulation of meal macronutrient may be a useful way to modulate meal-induced thermogenesis (MIT) to induce increases in energy expenditure. The objective of this study was to examine in adolescents with obesity and of healthy weight and the effect of a high protein and high carbohydrate meal on MIT. Methods: An acute cross-over study with adolescents aged 11–19 years was undertaken. Participants consumed in random order, a high 79% carbohydrate (HCHO), and a high 55% protein (HP) meal (adjusted to 25% of energy requirements). MIT and subjective appetite were assessed for 4 h postprandial and an ad libitum lunch served. Data calculated as total AUC and expressed as mean ± SEM. Results: Thirteen adolescents with obesity (mean BMI z score 2.3 ± 0.1) and 13 healthy weight (BMI z score 0.0 ± 0.2) participated. Mean MIT (% of energy intake) was greater after the HP (8.19 ± 0.709%) compared with the HCHO meal (4.36 ± 0.480%) (p < 0.001). The HP compared with the HCHO meal promoted greater fullness (12,994 ± 1208 vs 11,186 ± 1220 mm/4 h) (p = 0.016) and decreased hunger (8868 ± 1315 vs 10984 mm ± 1438 mm/4 h) (p = 0.007). These effects observed were independent of body weight. Conclusions: High protein meals can increase MIT and fullness and reduce hunger compared with high carbohydrate meals in adolescents with obesity. Future research is warranted to determine if MIT can be targeted through manipulation of dietary choices to support weight management strategies. Trial registration: This study is registered with the Australian New Zealand Clinical Trials Registry (ANZCTR). Trial ID: ACTRN12612001066875.

KW - Acute feeding

KW - Adolescent

KW - Macronutrients

KW - Meal-induced thermogenesis

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=85050310722&partnerID=8YFLogxK

U2 - 10.1007/s00394-018-1783-1

DO - 10.1007/s00394-018-1783-1

M3 - Article

VL - 58

SP - 2327

EP - 2333

JO - European Journal of Nutrition

JF - European Journal of Nutrition

SN - 1436-6207

IS - 6

ER -