Effect of iron chelation on myocardial infarct size and oxidative stress in ST-elevation-myocardial infarction

William Chan; Andrew J Taylor; Andris Ellims; Lisa Lefkovits; Chiew Wong; Bronwyn A Kingwell; Alaina K Natoli; Kevin David Croft; Trevor A Mori; David M Kaye; Anthony M Dart; Stephen Duffy

doi:10.1161/CIRCINTERVENTIONS.111.966226

Effect of iron chelation on myocardial infarct size and oxidative stress in ST-elevation-myocardial infarction

William Chan, Andrew J Taylor, Andris Ellims, Lisa Lefkovits, Chiew Wong, Bronwyn A Kingwell, Alaina K Natoli, Kevin David Croft, Trevor A Mori, David M Kaye, Anthony M Dart, Stephen Duffy

Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

97 Citations (Scopus)

Abstract

Experimental studies suggest that deferoxamine (DFO) limits the generation of reactive oxygen species by chelating redox-active iron and thereby may reduce ischemia-reperfusion injury and myocardial infarct (MI) size. We investigated whether DFO administered before reperfusion by primary percutaneous coronary intervention (PPCI) would ameliorate oxidative stress and MI size.

Original language	English
Pages (from-to)	270 - 278
Number of pages	9
Journal	Circulation: Cardiovascular Interventions
Volume	5
Issue number	2
DOIs	https://doi.org/10.1161/CIRCINTERVENTIONS.111.966226
Publication status	Published - 2012

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Chan, W., Taylor, A. J., Ellims, A., Lefkovits, L., Wong, C., Kingwell, B. A., Natoli, A. K., Croft, K. D., Mori, T. A., Kaye, D. M., Dart, A. M., & Duffy, S. (2012). Effect of iron chelation on myocardial infarct size and oxidative stress in ST-elevation-myocardial infarction. Circulation: Cardiovascular Interventions, 5(2), 270 - 278. https://doi.org/10.1161/CIRCINTERVENTIONS.111.966226

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title = "Effect of iron chelation on myocardial infarct size and oxidative stress in ST-elevation-myocardial infarction",

abstract = "Experimental studies suggest that deferoxamine (DFO) limits the generation of reactive oxygen species by chelating redox-active iron and thereby may reduce ischemia-reperfusion injury and myocardial infarct (MI) size. We investigated whether DFO administered before reperfusion by primary percutaneous coronary intervention (PPCI) would ameliorate oxidative stress and MI size.",

author = "William Chan and Taylor, \{Andrew J\} and Andris Ellims and Lisa Lefkovits and Chiew Wong and Kingwell, \{Bronwyn A\} and Natoli, \{Alaina K\} and Croft, \{Kevin David\} and Mori, \{Trevor A\} and Kaye, \{David M\} and Dart, \{Anthony M\} and Stephen Duffy",

year = "2012",

doi = "10.1161/CIRCINTERVENTIONS.111.966226",

language = "English",

volume = "5",

pages = "270 -- 278",

journal = "Circulation: Cardiovascular Interventions",

issn = "1941-7640",

publisher = "American Heart Association",

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Chan, W , Taylor, AJ, Ellims, A, Lefkovits, L, Wong, C, Kingwell, BA, Natoli, AK, Croft, KD, Mori, TA, Kaye, DM , Dart, AM & Duffy, S 2012, 'Effect of iron chelation on myocardial infarct size and oxidative stress in ST-elevation-myocardial infarction', Circulation: Cardiovascular Interventions, vol. 5, no. 2, pp. 270 - 278. https://doi.org/10.1161/CIRCINTERVENTIONS.111.966226

TY - JOUR

T1 - Effect of iron chelation on myocardial infarct size and oxidative stress in ST-elevation-myocardial infarction

AU - Chan, William

AU - Taylor, Andrew J

AU - Ellims, Andris

AU - Lefkovits, Lisa

AU - Wong, Chiew

AU - Kingwell, Bronwyn A

AU - Natoli, Alaina K

AU - Croft, Kevin David

AU - Mori, Trevor A

AU - Kaye, David M

AU - Dart, Anthony M

AU - Duffy, Stephen

PY - 2012

Y1 - 2012

N2 - Experimental studies suggest that deferoxamine (DFO) limits the generation of reactive oxygen species by chelating redox-active iron and thereby may reduce ischemia-reperfusion injury and myocardial infarct (MI) size. We investigated whether DFO administered before reperfusion by primary percutaneous coronary intervention (PPCI) would ameliorate oxidative stress and MI size.

AB - Experimental studies suggest that deferoxamine (DFO) limits the generation of reactive oxygen species by chelating redox-active iron and thereby may reduce ischemia-reperfusion injury and myocardial infarct (MI) size. We investigated whether DFO administered before reperfusion by primary percutaneous coronary intervention (PPCI) would ameliorate oxidative stress and MI size.

UR - http://circinterventions.ahajournals.org/content/5/2/270.full.pdf

UR - https://www.scopus.com/pages/publications/84860810441

U2 - 10.1161/CIRCINTERVENTIONS.111.966226

DO - 10.1161/CIRCINTERVENTIONS.111.966226

M3 - Article

SN - 1941-7640

VL - 5

SP - 270

EP - 278

JO - Circulation: Cardiovascular Interventions

JF - Circulation: Cardiovascular Interventions

IS - 2

ER -

Effect of iron chelation on myocardial infarct size and oxidative stress in ST-elevation-myocardial infarction

Abstract

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