Effect of iron chelation on myocardial infarct size and oxidative stress in ST-elevation-myocardial infarction

William Chan, Andrew J Taylor, Andris Ellims, Lisa Lefkovits, Chiew Wong, Bronwyn A Kingwell, Alaina K Natoli, Kevin David Croft, Trevor A Mori, David M Kaye, Anthony M Dart, Stephen Duffy

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Abstract

Experimental studies suggest that deferoxamine (DFO) limits the generation of reactive oxygen species by chelating redox-active iron and thereby may reduce ischemia-reperfusion injury and myocardial infarct (MI) size. We investigated whether DFO administered before reperfusion by primary percutaneous coronary intervention (PPCI) would ameliorate oxidative stress and MI size.
Original languageEnglish
Pages (from-to)270 - 278
Number of pages9
JournalCirculation: Cardiovascular Interventions
Volume5
Issue number2
DOIs
Publication statusPublished - 2012

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