Effect of infant immunisation with meningococcus serogroup C-CRM197 conjugate vaccine on diphtheria immunity and reactogenicity in pre-school aged children

Jodie McVernon, Jenny MacLennan, Elizabeth Clutterbuck, Jim Buttery, E. Richard Moxon

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)


The majority of Men C conjugate vaccines given in the UK use CRM197, a mutant diphtheria toxoid, as their protein carrier. We studied the effects of prior immunisation with Men C-CRM197 conjugate vaccine on immunity to diphtheria in 193 children before and after a booster dose of Men C at 4 years. Baseline diphtheria antibodies were higher in children given four previous doses of Men C (P<0.0001) and tended to be higher following boosting in those who had received three or four doses. This enhanced immunity was not associated with increased reactogenicity.

Original languageEnglish
Pages (from-to)2573-2579
Number of pages7
Issue number19-20
Publication statusPublished - 2 Jun 2003
Externally publishedYes


  • Diphtheria
  • Immunisation schedule
  • Meningococcal vaccines

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