Effect of infant immunisation with meningococcus serogroup C-CRM197 conjugate vaccine on diphtheria immunity and reactogenicity in pre-school aged children

Jodie McVernon; Jenny MacLennan; Elizabeth Clutterbuck; Jim Buttery; E. Richard Moxon

doi:10.1016/S0264-410X(03)00058-6

Effect of infant immunisation with meningococcus serogroup C-CRM₁₉₇ conjugate vaccine on diphtheria immunity and reactogenicity in pre-school aged children

Jodie McVernon, Jenny MacLennan, Elizabeth Clutterbuck, Jim Buttery, E. Richard Moxon

Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)

Abstract

The majority of Men C conjugate vaccines given in the UK use CRM₁₉₇, a mutant diphtheria toxoid, as their protein carrier. We studied the effects of prior immunisation with Men C-CRM₁₉₇ conjugate vaccine on immunity to diphtheria in 193 children before and after a booster dose of Men C at 4 years. Baseline diphtheria antibodies were higher in children given four previous doses of Men C (P<0.0001) and tended to be higher following boosting in those who had received three or four doses. This enhanced immunity was not associated with increased reactogenicity.

Original language	English
Pages (from-to)	2573-2579
Number of pages	7
Journal	Vaccine
Volume	21
Issue number	19-20
DOIs	https://doi.org/10.1016/S0264-410X(03)00058-6
Publication status	Published - 2 Jun 2003
Externally published	Yes

Keywords

Diphtheria
Immunisation schedule
Meningococcal vaccines

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0264-410X(03)00058-6

Cite this

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title = "Effect of infant immunisation with meningococcus serogroup C-CRM197 conjugate vaccine on diphtheria immunity and reactogenicity in pre-school aged children",

abstract = "The majority of Men C conjugate vaccines given in the UK use CRM197, a mutant diphtheria toxoid, as their protein carrier. We studied the effects of prior immunisation with Men C-CRM197 conjugate vaccine on immunity to diphtheria in 193 children before and after a booster dose of Men C at 4 years. Baseline diphtheria antibodies were higher in children given four previous doses of Men C (P<0.0001) and tended to be higher following boosting in those who had received three or four doses. This enhanced immunity was not associated with increased reactogenicity.",

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AU - MacLennan, Jenny

AU - Clutterbuck, Elizabeth

AU - Buttery, Jim

AU - Moxon, E. Richard

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AB - The majority of Men C conjugate vaccines given in the UK use CRM197, a mutant diphtheria toxoid, as their protein carrier. We studied the effects of prior immunisation with Men C-CRM197 conjugate vaccine on immunity to diphtheria in 193 children before and after a booster dose of Men C at 4 years. Baseline diphtheria antibodies were higher in children given four previous doses of Men C (P<0.0001) and tended to be higher following boosting in those who had received three or four doses. This enhanced immunity was not associated with increased reactogenicity.

KW - Diphtheria

KW - Immunisation schedule

KW - Meningococcal vaccines

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