Effect of high-dose fluticasone propionate on bone density and metabolism in children with asthma

Amanda L Griffiths, Derrick Sim, Boyd J G Strauss, Christine P Rodda, David Armstrong, Nicholas Freezer

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Abstract

Summary. Significant concern remains over the long-term side effects of inhaled steroids. This cross-sectional study evaluates the effect of high-dose inhaled fluticasone propionate (FP) on biochemical markers of bone metabolism and bone density in children with asthma. Children with chronic asthma using FP 1,000 mcg daily for at least 6 months, and healthy controls, were entered in the study. No children had taken oral prednisolone within the previous month. Fasting morning serum was analyzed for bone formation markers, and spot urine for bone resorption markers. Dual-energy X-ray absorptiometry (DEXA) results were reviewed in a subgroup of patients. Forty-nine children with asthma and 32 controls were recruited. The mean FP dose was 771.2 253.35 mcg/m2/day. Unpaired t-test analysis revealed no significant difference in biochemical markers studied. In subjects with asthma; 13 of 37 (35.1 ) had lumbar spine density more than one standard deviation below the mean (PA?0.001). This fell to 6/37 (16.2 ) with bone age correction (NS). In conclusion, no significant reduction in bone metabolism or bone agecorrected bone mineral density was observed in children with asthma on prolonged high doses of inhaled FP.
Original languageEnglish
Pages (from-to)116 - 121
Number of pages6
JournalPediatric Pulmonology
Volume37
DOIs
Publication statusPublished - 2004

Cite this

Griffiths, Amanda L ; Sim, Derrick ; Strauss, Boyd J G ; Rodda, Christine P ; Armstrong, David ; Freezer, Nicholas. / Effect of high-dose fluticasone propionate on bone density and metabolism in children with asthma. In: Pediatric Pulmonology. 2004 ; Vol. 37. pp. 116 - 121.
@article{f0f7ce9c8f454c4b8cfa8ca000d27d4e,
title = "Effect of high-dose fluticasone propionate on bone density and metabolism in children with asthma",
abstract = "Summary. Significant concern remains over the long-term side effects of inhaled steroids. This cross-sectional study evaluates the effect of high-dose inhaled fluticasone propionate (FP) on biochemical markers of bone metabolism and bone density in children with asthma. Children with chronic asthma using FP 1,000 mcg daily for at least 6 months, and healthy controls, were entered in the study. No children had taken oral prednisolone within the previous month. Fasting morning serum was analyzed for bone formation markers, and spot urine for bone resorption markers. Dual-energy X-ray absorptiometry (DEXA) results were reviewed in a subgroup of patients. Forty-nine children with asthma and 32 controls were recruited. The mean FP dose was 771.2 253.35 mcg/m2/day. Unpaired t-test analysis revealed no significant difference in biochemical markers studied. In subjects with asthma; 13 of 37 (35.1 ) had lumbar spine density more than one standard deviation below the mean (PA?0.001). This fell to 6/37 (16.2 ) with bone age correction (NS). In conclusion, no significant reduction in bone metabolism or bone agecorrected bone mineral density was observed in children with asthma on prolonged high doses of inhaled FP.",
author = "Griffiths, {Amanda L} and Derrick Sim and Strauss, {Boyd J G} and Rodda, {Christine P} and David Armstrong and Nicholas Freezer",
year = "2004",
doi = "10.1002/ppul.10396",
language = "English",
volume = "37",
pages = "116 -- 121",
journal = "Pediatric Pulmonology",
issn = "8755-6863",
publisher = "Wiley-Blackwell",

}

Effect of high-dose fluticasone propionate on bone density and metabolism in children with asthma. / Griffiths, Amanda L; Sim, Derrick; Strauss, Boyd J G; Rodda, Christine P; Armstrong, David; Freezer, Nicholas.

In: Pediatric Pulmonology, Vol. 37, 2004, p. 116 - 121.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Effect of high-dose fluticasone propionate on bone density and metabolism in children with asthma

AU - Griffiths, Amanda L

AU - Sim, Derrick

AU - Strauss, Boyd J G

AU - Rodda, Christine P

AU - Armstrong, David

AU - Freezer, Nicholas

PY - 2004

Y1 - 2004

N2 - Summary. Significant concern remains over the long-term side effects of inhaled steroids. This cross-sectional study evaluates the effect of high-dose inhaled fluticasone propionate (FP) on biochemical markers of bone metabolism and bone density in children with asthma. Children with chronic asthma using FP 1,000 mcg daily for at least 6 months, and healthy controls, were entered in the study. No children had taken oral prednisolone within the previous month. Fasting morning serum was analyzed for bone formation markers, and spot urine for bone resorption markers. Dual-energy X-ray absorptiometry (DEXA) results were reviewed in a subgroup of patients. Forty-nine children with asthma and 32 controls were recruited. The mean FP dose was 771.2 253.35 mcg/m2/day. Unpaired t-test analysis revealed no significant difference in biochemical markers studied. In subjects with asthma; 13 of 37 (35.1 ) had lumbar spine density more than one standard deviation below the mean (PA?0.001). This fell to 6/37 (16.2 ) with bone age correction (NS). In conclusion, no significant reduction in bone metabolism or bone agecorrected bone mineral density was observed in children with asthma on prolonged high doses of inhaled FP.

AB - Summary. Significant concern remains over the long-term side effects of inhaled steroids. This cross-sectional study evaluates the effect of high-dose inhaled fluticasone propionate (FP) on biochemical markers of bone metabolism and bone density in children with asthma. Children with chronic asthma using FP 1,000 mcg daily for at least 6 months, and healthy controls, were entered in the study. No children had taken oral prednisolone within the previous month. Fasting morning serum was analyzed for bone formation markers, and spot urine for bone resorption markers. Dual-energy X-ray absorptiometry (DEXA) results were reviewed in a subgroup of patients. Forty-nine children with asthma and 32 controls were recruited. The mean FP dose was 771.2 253.35 mcg/m2/day. Unpaired t-test analysis revealed no significant difference in biochemical markers studied. In subjects with asthma; 13 of 37 (35.1 ) had lumbar spine density more than one standard deviation below the mean (PA?0.001). This fell to 6/37 (16.2 ) with bone age correction (NS). In conclusion, no significant reduction in bone metabolism or bone agecorrected bone mineral density was observed in children with asthma on prolonged high doses of inhaled FP.

UR - http://www3.interscience.wiley.com.ezproxy.lib.monash.edu.au/cgi-bin/fulltext/107061107/PDFSTART

U2 - 10.1002/ppul.10396

DO - 10.1002/ppul.10396

M3 - Article

VL - 37

SP - 116

EP - 121

JO - Pediatric Pulmonology

JF - Pediatric Pulmonology

SN - 8755-6863

ER -