Effect of GB virus C coinfection on response to antiretroviral treatment in human immunodeficiency virus-infected patients

Benigno Rodriguez, Ian Woolley, Michael M. Lederman, Dietmar Zdunek, Georg Hess, Hernán Valdez

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    Abstract

    To study how GB virus C (GBV-C) coinfection affects the response to highly active antiretroviral therapy (HAART), 146 human immunodeficiency virus (HIV)-infected patients were tested for GBV-C RNA and antibodies against GBV-C E2 protein, and responses to HAART were evaluated. GBV-C-infected patients exhibited a complete virological response to HAART more often than patients with GBV-C and had a greater increase in median CD4 cell count and a marginally greater median HIV RNA level decrease. This association was found to be independent of baseline CD4 cell count and plasma HIV RNA, which indicates that an association exists between GBV-C infection and response to HAART.

    Original languageEnglish
    Pages (from-to)504-507
    Number of pages4
    JournalJournal of Infectious Diseases
    Volume187
    Issue number3
    DOIs
    Publication statusPublished - 1 Feb 2003

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