Effect of enalapril on aortic smooth muscle cell polyploidy in the spontaneously hypertensive rat

M. Jane Black, Michael A. Adams, Alexander Bobik, Julie H. Campbell, Gordon R. Campbell

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Abstract

The angiotensin converting enzyme (ACE) inhibitor enalapril was used to examine the ef-fects of inhibition, regression and redevelopment of hypertension on the ploidy of aortic smooth muscle cells in spontaneously hypertensive rats (SHR).

The incidence of polyploidy cells, as determined by flow cytometric DNA analysis, di-rectly paralleled changes in systolic blood pressure. When the development of hyperten-sion was inhibited by treatment with enalapril, the incidence of polyploid cells remained low compared with untreated age-matched SHR. Likewise, when the blood pressure of hypertensive animals was lowered by enalapril treatment, the incidence of polyploid cells decreased. Addition of enalapril to primary cultures of smooth muscle had no direct effect on proliferation or the incidence of polyploidy.

These results suggest that angiotensin II may be involved in the development of vascular smooth muscle polyploidy in vivo, either by a direct effect on the cells or indirectly by elevating blood pressure or by potentiation of sympathetic discharge.

Original languageEnglish
Pages (from-to)997-1003
Number of pages7
JournalJournal of Hypertension
Volume7
Issue number12
DOIs
Publication statusPublished - 1 Jan 1989

Keywords

  • Enalapril
  • Hypertension
  • Hypertension inhibition
  • Hypertension reversal
  • Polyploidy
  • Smooth muscle cells
  • Spontaneously hypertensive rat

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