Effect of dietary advanced glycation end products on inflammation and cardiovascular risks in healthy overweight adults: A randomised crossover trial

Estifanos Baye, Maximilian P.J. De Courten, Karen Walker, Sanjeeva Ranasinha, Arul Earnest, Josephine M. Forbes, Barbora De Courten

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Diets high in advanced glycation end products (AGEs) are thought to be detrimental to cardiovascular health. However, there remains uncertainty about the beneficial effect of a low AGE diet on cardiovascular risk factors and inflammatory markers in overweight individuals. We thus performed a randomised, double blind, crossover trial to determine whether consumption of low AGE diets reduce inflammation and cardiovascular risks in overweight and obese otherwise healthy adults. All participants (n = 20) consumed low and high AGE diets alternately for two weeks and separated by a four week washout period. Low AGE diets did not change systolic (p = 0.2) and diastolic blood pressure (p = 0.3), mean arterial pressure (p = 0.8) and pulse pressure (p = 0.2) compared to high AGE diets. Change in total cholesterol (p = 0.3), low-density lipoprotein (p = 0.7), high-density lipoprotein (p = 0.2), and triglycerides (p = 0.4) also did not differ and there was no difference in inflammatory markers: interleukin-6 (p = 0.6), monocyte chemoattractant protein-1 (p = 0.9), tumour necrosis factor α (p = 0.2), C-reactive protein (p = 0.6) and nuclear factor kappa beta (p = 0.2). These findings indicate that consumption of low AGE diets for two weeks did not improve the inflammatory and cardiovascular profiles of overweight and obese adults.

Original languageEnglish
Article number4123
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - 1 Dec 2017

Cite this

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title = "Effect of dietary advanced glycation end products on inflammation and cardiovascular risks in healthy overweight adults: A randomised crossover trial",
abstract = "Diets high in advanced glycation end products (AGEs) are thought to be detrimental to cardiovascular health. However, there remains uncertainty about the beneficial effect of a low AGE diet on cardiovascular risk factors and inflammatory markers in overweight individuals. We thus performed a randomised, double blind, crossover trial to determine whether consumption of low AGE diets reduce inflammation and cardiovascular risks in overweight and obese otherwise healthy adults. All participants (n = 20) consumed low and high AGE diets alternately for two weeks and separated by a four week washout period. Low AGE diets did not change systolic (p = 0.2) and diastolic blood pressure (p = 0.3), mean arterial pressure (p = 0.8) and pulse pressure (p = 0.2) compared to high AGE diets. Change in total cholesterol (p = 0.3), low-density lipoprotein (p = 0.7), high-density lipoprotein (p = 0.2), and triglycerides (p = 0.4) also did not differ and there was no difference in inflammatory markers: interleukin-6 (p = 0.6), monocyte chemoattractant protein-1 (p = 0.9), tumour necrosis factor α (p = 0.2), C-reactive protein (p = 0.6) and nuclear factor kappa beta (p = 0.2). These findings indicate that consumption of low AGE diets for two weeks did not improve the inflammatory and cardiovascular profiles of overweight and obese adults.",
author = "Estifanos Baye and {De Courten}, {Maximilian P.J.} and Karen Walker and Sanjeeva Ranasinha and Arul Earnest and Forbes, {Josephine M.} and {De Courten}, Barbora",
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Effect of dietary advanced glycation end products on inflammation and cardiovascular risks in healthy overweight adults : A randomised crossover trial. / Baye, Estifanos; De Courten, Maximilian P.J.; Walker, Karen; Ranasinha, Sanjeeva; Earnest, Arul; Forbes, Josephine M.; De Courten, Barbora.

In: Scientific Reports, Vol. 7, No. 1, 4123, 01.12.2017.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Effect of dietary advanced glycation end products on inflammation and cardiovascular risks in healthy overweight adults

T2 - A randomised crossover trial

AU - Baye, Estifanos

AU - De Courten, Maximilian P.J.

AU - Walker, Karen

AU - Ranasinha, Sanjeeva

AU - Earnest, Arul

AU - Forbes, Josephine M.

AU - De Courten, Barbora

PY - 2017/12/1

Y1 - 2017/12/1

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