Abstract
Ten normal men were given three monthly intramuscular injections of 200mg of depot medroxyprogesterone acetate (DMPA) and 250mg of testosterone oenanthate (TE) as part of a male contraceptive trial. During the three months of treatment, serum high density lipoprotein cholesterol (HDL-C) and the HDL-C:LDL-C (low density lipoprotein cholesterol) ratio were significantly depressed compared to baseline. Although the long-term effect of this alteration in lipoprotein cholesterol metabolism in normolipidaemic men is currently uncertain, these results suggest that the potential cardiovascular risks of progestagen-containing regimens for male contraception will have to be seriously considered.
Original language | English |
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Pages (from-to) | 63-71 |
Number of pages | 9 |
Journal | Contraception |
Volume | 41 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 1990 |
Externally published | Yes |