Effect of depot medroxyprogesteroneacetate and testosteroneoenanthate on serum lipoproteins in man

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Ten normal men were given three monthly intramuscular injections of 200mg of depot medroxyprogesterone acetate (DMPA) and 250mg of testosterone oenanthate (TE) as part of a male contraceptive trial. During the three months of treatment, serum high density lipoprotein cholesterol (HDL-C) and the HDL-C:LDL-C (low density lipoprotein cholesterol) ratio were significantly depressed compared to baseline. Although the long-term effect of this alteration in lipoprotein cholesterol metabolism in normolipidaemic men is currently uncertain, these results suggest that the potential cardiovascular risks of progestagen-containing regimens for male contraception will have to be seriously considered.

Original languageEnglish
Pages (from-to)63-71
Number of pages9
Issue number1
Publication statusPublished - Jan 1990
Externally publishedYes

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