Effect of cryptorchidism on steroidogenic and mitogenic activities in rat testicular interstitial fluid

G. P. Risbridger, A. E. Drummond, J. B. Kerr, D. M. De Kretser

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Abstract

There was a significant (P<0.05) and consistent increase in the potency of steroidogenic stimulatory activity (testosterone production by purified Leydig cells in vitro) in testicular interstitial fluid of the cryptorchid compared to the scrotal testis from 1 to 4 weeks after the induction of unilateral cryptorchidism. In contrast, the level of mitogenic activity ([3H]thymidine incorporation into 3T3 cells) was not significantly different between interstitial fluid from cryptorchid and scrotal testes for up to 4 weeks after surgery. These results indicate that the steroidogenic activity and the mitogenic activity are due to different, as yet unidentified, factors in testicular interstitial fluid.

Original languageEnglish
Pages (from-to)617-624
Number of pages8
JournalJournal of Reproduction and Fertility
Volume81
Issue number2
Publication statusPublished - 1987

Cite this

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title = "Effect of cryptorchidism on steroidogenic and mitogenic activities in rat testicular interstitial fluid",
abstract = "There was a significant (P<0.05) and consistent increase in the potency of steroidogenic stimulatory activity (testosterone production by purified Leydig cells in vitro) in testicular interstitial fluid of the cryptorchid compared to the scrotal testis from 1 to 4 weeks after the induction of unilateral cryptorchidism. In contrast, the level of mitogenic activity ([3H]thymidine incorporation into 3T3 cells) was not significantly different between interstitial fluid from cryptorchid and scrotal testes for up to 4 weeks after surgery. These results indicate that the steroidogenic activity and the mitogenic activity are due to different, as yet unidentified, factors in testicular interstitial fluid.",
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Effect of cryptorchidism on steroidogenic and mitogenic activities in rat testicular interstitial fluid. / Risbridger, G. P.; Drummond, A. E.; Kerr, J. B.; De Kretser, D. M.

In: Journal of Reproduction and Fertility, Vol. 81, No. 2, 1987, p. 617-624.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Risbridger, G. P.

AU - Drummond, A. E.

AU - Kerr, J. B.

AU - De Kretser, D. M.

PY - 1987

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AB - There was a significant (P<0.05) and consistent increase in the potency of steroidogenic stimulatory activity (testosterone production by purified Leydig cells in vitro) in testicular interstitial fluid of the cryptorchid compared to the scrotal testis from 1 to 4 weeks after the induction of unilateral cryptorchidism. In contrast, the level of mitogenic activity ([3H]thymidine incorporation into 3T3 cells) was not significantly different between interstitial fluid from cryptorchid and scrotal testes for up to 4 weeks after surgery. These results indicate that the steroidogenic activity and the mitogenic activity are due to different, as yet unidentified, factors in testicular interstitial fluid.

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