Effect of birth weight on life-course blood pressure levels among children born premature

The Cardiovascular Risk in Young Finns Study

Markus Juonala, Michael M H Cheung, Matthew A. Sabin, David Burgner, Michael R Skilton, Mika Kähönen, Nina Hutri-Kähönen, Terho Lehtimäki, Antti Jula, Tomi Laitinen, Eero Jokinen, Leena Taittonen, Päivi Tossavainen, Jorma S A Viikari, Costan G. Magnussen, Olli T Raitakari

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objectives: Both fetal growth restriction and prematurity have been associated with elevated blood pressure (BP). However, their combined effects on adult BP are unclear. Methods: Our analyses were based on 1756 participants in the population-based Cardiovascular Risk in Young Finns Study who had information on birth weight and gestational age, together with longitudinal data on cardiovascular risk markers from age 3-18 years in 1980 to age 34-49 years in 2011. Three groups were defined by birth data: those born at term (term); those born preterm (<37 weeks) with an appropriate birth weight (>-1 SD z score according to national sex and gestational week-stratified data) for gestational age (preterm appropriate birth weight for gestational age); and those born preterm with low birth weight (≤-1 SD z score) for gestational age [preterm small birth weight for gestational age (SGA)]. Results: There were no differences between the three groups in BP at baseline, but at the 31-year follow-up (mean age 41 years), mean SBP in the preterm SGA group was 7.2 mmHg (95% confidence interval=2.3-12.1 mmHg, P=0.004) higher than the preterm appropriate birth weight for gestational age group and 7.3 mmHg (95% confidence interval=5.2-9.4 mmHg, P<0.0001) higher than the term group, adjusted for age and sex. In addition, preterm SGA individuals had a higher prevalence of adult hypertension compared with those born at term (36.9 vs. 25.4%; age, sex, and risk factors adjusted P=0.006). Conclusion: These longitudinal data suggest that elevated BP levels associated with prematurity are more likely to be present in those with fetal growth restriction.

Original languageEnglish
Pages (from-to)1542-1548
Number of pages7
JournalJournal of Hypertension
Volume33
Issue number8
DOIs
Publication statusPublished - 11 Aug 2015

Keywords

  • birth weight
  • blood pressure
  • prematurity

Cite this

Juonala, Markus ; Cheung, Michael M H ; Sabin, Matthew A. ; Burgner, David ; Skilton, Michael R ; Kähönen, Mika ; Hutri-Kähönen, Nina ; Lehtimäki, Terho ; Jula, Antti ; Laitinen, Tomi ; Jokinen, Eero ; Taittonen, Leena ; Tossavainen, Päivi ; Viikari, Jorma S A ; Magnussen, Costan G. ; Raitakari, Olli T. / Effect of birth weight on life-course blood pressure levels among children born premature : The Cardiovascular Risk in Young Finns Study. In: Journal of Hypertension. 2015 ; Vol. 33, No. 8. pp. 1542-1548.
@article{9b485e0bbe6145a2acff277d3f6911a8,
title = "Effect of birth weight on life-course blood pressure levels among children born premature: The Cardiovascular Risk in Young Finns Study",
abstract = "Objectives: Both fetal growth restriction and prematurity have been associated with elevated blood pressure (BP). However, their combined effects on adult BP are unclear. Methods: Our analyses were based on 1756 participants in the population-based Cardiovascular Risk in Young Finns Study who had information on birth weight and gestational age, together with longitudinal data on cardiovascular risk markers from age 3-18 years in 1980 to age 34-49 years in 2011. Three groups were defined by birth data: those born at term (term); those born preterm (<37 weeks) with an appropriate birth weight (>-1 SD z score according to national sex and gestational week-stratified data) for gestational age (preterm appropriate birth weight for gestational age); and those born preterm with low birth weight (≤-1 SD z score) for gestational age [preterm small birth weight for gestational age (SGA)]. Results: There were no differences between the three groups in BP at baseline, but at the 31-year follow-up (mean age 41 years), mean SBP in the preterm SGA group was 7.2 mmHg (95{\%} confidence interval=2.3-12.1 mmHg, P=0.004) higher than the preterm appropriate birth weight for gestational age group and 7.3 mmHg (95{\%} confidence interval=5.2-9.4 mmHg, P<0.0001) higher than the term group, adjusted for age and sex. In addition, preterm SGA individuals had a higher prevalence of adult hypertension compared with those born at term (36.9 vs. 25.4{\%}; age, sex, and risk factors adjusted P=0.006). Conclusion: These longitudinal data suggest that elevated BP levels associated with prematurity are more likely to be present in those with fetal growth restriction.",
keywords = "birth weight, blood pressure, prematurity",
author = "Markus Juonala and Cheung, {Michael M H} and Sabin, {Matthew A.} and David Burgner and Skilton, {Michael R} and Mika K{\"a}h{\"o}nen and Nina Hutri-K{\"a}h{\"o}nen and Terho Lehtim{\"a}ki and Antti Jula and Tomi Laitinen and Eero Jokinen and Leena Taittonen and P{\"a}ivi Tossavainen and Viikari, {Jorma S A} and Magnussen, {Costan G.} and Raitakari, {Olli T}",
year = "2015",
month = "8",
day = "11",
doi = "10.1097/HJH.0000000000000612",
language = "English",
volume = "33",
pages = "1542--1548",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams & Wilkins",
number = "8",

}

Juonala, M, Cheung, MMH, Sabin, MA, Burgner, D, Skilton, MR, Kähönen, M, Hutri-Kähönen, N, Lehtimäki, T, Jula, A, Laitinen, T, Jokinen, E, Taittonen, L, Tossavainen, P, Viikari, JSA, Magnussen, CG & Raitakari, OT 2015, 'Effect of birth weight on life-course blood pressure levels among children born premature: The Cardiovascular Risk in Young Finns Study', Journal of Hypertension, vol. 33, no. 8, pp. 1542-1548. https://doi.org/10.1097/HJH.0000000000000612

Effect of birth weight on life-course blood pressure levels among children born premature : The Cardiovascular Risk in Young Finns Study. / Juonala, Markus; Cheung, Michael M H; Sabin, Matthew A.; Burgner, David; Skilton, Michael R; Kähönen, Mika; Hutri-Kähönen, Nina; Lehtimäki, Terho; Jula, Antti; Laitinen, Tomi; Jokinen, Eero; Taittonen, Leena; Tossavainen, Päivi; Viikari, Jorma S A; Magnussen, Costan G.; Raitakari, Olli T.

In: Journal of Hypertension, Vol. 33, No. 8, 11.08.2015, p. 1542-1548.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Effect of birth weight on life-course blood pressure levels among children born premature

T2 - The Cardiovascular Risk in Young Finns Study

AU - Juonala, Markus

AU - Cheung, Michael M H

AU - Sabin, Matthew A.

AU - Burgner, David

AU - Skilton, Michael R

AU - Kähönen, Mika

AU - Hutri-Kähönen, Nina

AU - Lehtimäki, Terho

AU - Jula, Antti

AU - Laitinen, Tomi

AU - Jokinen, Eero

AU - Taittonen, Leena

AU - Tossavainen, Päivi

AU - Viikari, Jorma S A

AU - Magnussen, Costan G.

AU - Raitakari, Olli T

PY - 2015/8/11

Y1 - 2015/8/11

N2 - Objectives: Both fetal growth restriction and prematurity have been associated with elevated blood pressure (BP). However, their combined effects on adult BP are unclear. Methods: Our analyses were based on 1756 participants in the population-based Cardiovascular Risk in Young Finns Study who had information on birth weight and gestational age, together with longitudinal data on cardiovascular risk markers from age 3-18 years in 1980 to age 34-49 years in 2011. Three groups were defined by birth data: those born at term (term); those born preterm (<37 weeks) with an appropriate birth weight (>-1 SD z score according to national sex and gestational week-stratified data) for gestational age (preterm appropriate birth weight for gestational age); and those born preterm with low birth weight (≤-1 SD z score) for gestational age [preterm small birth weight for gestational age (SGA)]. Results: There were no differences between the three groups in BP at baseline, but at the 31-year follow-up (mean age 41 years), mean SBP in the preterm SGA group was 7.2 mmHg (95% confidence interval=2.3-12.1 mmHg, P=0.004) higher than the preterm appropriate birth weight for gestational age group and 7.3 mmHg (95% confidence interval=5.2-9.4 mmHg, P<0.0001) higher than the term group, adjusted for age and sex. In addition, preterm SGA individuals had a higher prevalence of adult hypertension compared with those born at term (36.9 vs. 25.4%; age, sex, and risk factors adjusted P=0.006). Conclusion: These longitudinal data suggest that elevated BP levels associated with prematurity are more likely to be present in those with fetal growth restriction.

AB - Objectives: Both fetal growth restriction and prematurity have been associated with elevated blood pressure (BP). However, their combined effects on adult BP are unclear. Methods: Our analyses were based on 1756 participants in the population-based Cardiovascular Risk in Young Finns Study who had information on birth weight and gestational age, together with longitudinal data on cardiovascular risk markers from age 3-18 years in 1980 to age 34-49 years in 2011. Three groups were defined by birth data: those born at term (term); those born preterm (<37 weeks) with an appropriate birth weight (>-1 SD z score according to national sex and gestational week-stratified data) for gestational age (preterm appropriate birth weight for gestational age); and those born preterm with low birth weight (≤-1 SD z score) for gestational age [preterm small birth weight for gestational age (SGA)]. Results: There were no differences between the three groups in BP at baseline, but at the 31-year follow-up (mean age 41 years), mean SBP in the preterm SGA group was 7.2 mmHg (95% confidence interval=2.3-12.1 mmHg, P=0.004) higher than the preterm appropriate birth weight for gestational age group and 7.3 mmHg (95% confidence interval=5.2-9.4 mmHg, P<0.0001) higher than the term group, adjusted for age and sex. In addition, preterm SGA individuals had a higher prevalence of adult hypertension compared with those born at term (36.9 vs. 25.4%; age, sex, and risk factors adjusted P=0.006). Conclusion: These longitudinal data suggest that elevated BP levels associated with prematurity are more likely to be present in those with fetal growth restriction.

KW - birth weight

KW - blood pressure

KW - prematurity

UR - http://www.scopus.com/inward/record.url?scp=84941253759&partnerID=8YFLogxK

U2 - 10.1097/HJH.0000000000000612

DO - 10.1097/HJH.0000000000000612

M3 - Article

VL - 33

SP - 1542

EP - 1548

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 8

ER -