Projects per year
Abstract
Antenatal glucocorticoids, exogenous surfactant, and positive end-expiratory pressure (PEEP) ventilation are commonly provided to preterm infants to enhance respiratory function after birth. It is unclear how these treatments interact to improve the transition to air-breathing at birth. We investigated the relative contribution of antenatal betamethasone, prophylactic surfactant, and PEEP (3 cmH2O) on functional residual capacity (FRC) and dynamic lung compliance (CDL) in preterm (28 day GA) rabbit kittens at birth. Kittens were delivered by cesarean section and mechanically ventilated. FRC was calculated from X-ray images, and CDL was measured using plethysmography. Without betamethasone, PEEP increased FRC recruitment and CDL. Surfactant did not further increase FRC, but significantly increased CDL. Betamethasone abolished the benefit of PEEP on FRC, but surfactant counteracted this effect of betamethasone. These findings indicate that low PEEP levels are insufficient to establish FRC at birth following betamethasone treatment. However, surfactant reversed the effect of betamethasone and when combined, these two treatments enhanced FRC recruitment irrespective of PEEP level.
Original language | English |
---|---|
Pages (from-to) | 750-759 |
Number of pages | 10 |
Journal | Journal of Applied Physiology |
Volume | 121 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Sept 2016 |
Keywords
- Betamethasone
- Functional residual capacity
- Positive end-expiratory pressure
- Preterm birth
- Surfactant
Projects
- 3 Finished
-
Low dose methods for detecting early lung disease using x-ray phase contrast imaging.
Kitchen, M. (Primary Chief Investigator (PCI)) & Hooper, S. (Chief Investigator (CI))
Australian Research Council (ARC), Monash University
30/03/11 → 17/04/17
Project: Research
-
Phase contrast X-ray imaging of the lung at birth
Hooper, S. (Primary Chief Investigator (PCI)), Hourigan, K. (Chief Investigator (CI)), Lewis, R. (Chief Investigator (CI)) & Thompson, B. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
2/01/08 → 31/12/10
Project: Research
-
Phase Contrast X-ray Imaging of the Lung
Lewis, R. (Primary Chief Investigator (PCI)), Hooper, S. (Chief Investigator (CI)) & Morgan, M. (Chief Investigator (CI))
Australian Research Council (ARC)
1/03/06 → 30/04/10
Project: Research