TY - JOUR
T1 - Effect of alendronate on vascular calcification in CKD stages 3 and 4: a pilot randomized controlled trial
AU - Toussaint, Nigel
AU - Lau, Kenneth
AU - Strauss, Boyd
AU - Polkinghorne, Kevan
AU - Kerr, Peter
PY - 2010
Y1 - 2010
N2 - BACKGROUND: Vascular calcification contributes to cardiovascular disease in patients with chronic kidney disease (CKD). Few studies have addressed interventions to decrease vascular calcification; however, experimental studies report benefits of bisphosphonates. Recent studies of hemodialysis patients also suggest benefits of bisphosphonates on vascular calcification; however, no study exists in nondialysis patients with CKD.
STUDY DESIGN: We conducted a randomized controlled trial to determine the effect of bisphosphonates on vascular calcification in patients with CKD.
AB - BACKGROUND: Vascular calcification contributes to cardiovascular disease in patients with chronic kidney disease (CKD). Few studies have addressed interventions to decrease vascular calcification; however, experimental studies report benefits of bisphosphonates. Recent studies of hemodialysis patients also suggest benefits of bisphosphonates on vascular calcification; however, no study exists in nondialysis patients with CKD.
STUDY DESIGN: We conducted a randomized controlled trial to determine the effect of bisphosphonates on vascular calcification in patients with CKD.
UR - https://www.scopus.com/pages/publications/77953687445
U2 - 10.1053/j.ajkd.2009.12.039
DO - 10.1053/j.ajkd.2009.12.039
M3 - Article
SN - 0272-6386
VL - 56
SP - 57
EP - 68
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 1
ER -
