Effect of alendronate on vascular calcification in CKD stages 3 and 4: a pilot randomized controlled trial

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BACKGROUND: Vascular calcification contributes to cardiovascular disease in patients with chronic kidney disease (CKD). Few studies have addressed interventions to decrease vascular calcification; however, experimental studies report benefits of bisphosphonates. Recent studies of hemodialysis patients also suggest benefits of bisphosphonates on vascular calcification; however, no study exists in nondialysis patients with CKD. STUDY DESIGN: We conducted a randomized controlled trial to determine the effect of bisphosphonates on vascular calcification in patients with CKD.
Original languageEnglish
Pages (from-to)57 - 68
Number of pages12
JournalAmerican Journal of Kidney Diseases
Issue number1
Publication statusPublished - 2010

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