Abstract
The protective effect of two types of vitamin E (α-tocopherol and γ-tocotrienol) in rats treated with diethylnitrosamine (DEN) and 2-acetylaminofluorene (AAF) were studied by determination of plasma alkaline phosphatase (ALP), plasma and liver microsomal y-glutamyl transpeptidase (GGT) activities, and blood glutathione (GSH). Rats treated with DEN/AAF had significantly elevated plasma and microsomal GGT, plasma ALP activities, and blood GSH levels compared with the normal controls (Ρ<0.05). Supplementation with vitamin E of normal controls did not affect the enzyme activities or blood GSH. in rats treated with DEN/AAF, vitamin E supplementation attenuated GGT and ALP activitiesand blood GSH levels. the optimum dose required for highest attenuation of the tumor marker enzyme activities was 34 mg/kg diet for α-tocopherol and 30 mg/kg diet for y-tocotrienol. Higher doses of the vitamin did not show further attenuation in the level of the tumor marker enzyme activities.
Original language | English |
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Pages (from-to) | 195-202 |
Number of pages | 8 |
Journal | Journal of Clinical Biochemistry and Nutrition |
Volume | 15 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1993 |
Externally published | Yes |
Keywords
- alkaline phosphatase
- hepatocarcinogenesis
- α-glutamyl transpeptidase
- α-tocopherol
- γ-tocotrienol