Efavirenz plasma concentrations did not predict cessation of therapy due to neuropsychiatric symptoms in a large randomized trial.

Tim R H Read, Dianne L Carey, Patrick Mallon, Anne Mijch, Ruth Goodall, Fleur Hudson, Handan C Wand, Sean Emery

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Abstract

To assess whether trial participants who ceased efavirenz (EFV) because of neuropsychiatric events had elevated plasma concentrations, we performed a retrospective case-control study. EFV levels were measured by high-performance liquid chromatography in stored plasma from 35 cases and 75 matched controls. All had taken EFV for at least 4 weeks. Median EFV concentrations did not differ (P = 0.77). Measurement of EFV levels in plasma collected at variable times after the last dose did not predict central nervous system intolerance.

Original languageEnglish
Pages (from-to)2222-2223
Number of pages2
JournalAIDS
Volume23
Issue number16
Publication statusPublished - 23 Oct 2009

Cite this

Read, T. R. H., Carey, D. L., Mallon, P., Mijch, A., Goodall, R., Hudson, F., ... Emery, S. (2009). Efavirenz plasma concentrations did not predict cessation of therapy due to neuropsychiatric symptoms in a large randomized trial. AIDS, 23(16), 2222-2223.
Read, Tim R H ; Carey, Dianne L ; Mallon, Patrick ; Mijch, Anne ; Goodall, Ruth ; Hudson, Fleur ; Wand, Handan C ; Emery, Sean. / Efavirenz plasma concentrations did not predict cessation of therapy due to neuropsychiatric symptoms in a large randomized trial. In: AIDS. 2009 ; Vol. 23, No. 16. pp. 2222-2223.
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Read, TRH, Carey, DL, Mallon, P, Mijch, A, Goodall, R, Hudson, F, Wand, HC & Emery, S 2009, 'Efavirenz plasma concentrations did not predict cessation of therapy due to neuropsychiatric symptoms in a large randomized trial.', AIDS, vol. 23, no. 16, pp. 2222-2223.

Efavirenz plasma concentrations did not predict cessation of therapy due to neuropsychiatric symptoms in a large randomized trial. / Read, Tim R H; Carey, Dianne L; Mallon, Patrick; Mijch, Anne; Goodall, Ruth; Hudson, Fleur; Wand, Handan C; Emery, Sean.

In: AIDS, Vol. 23, No. 16, 23.10.2009, p. 2222-2223.

Research output: Contribution to journalArticleResearchpeer-review

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