EEG spectral analysis of apnoeic events confirms visual scoring in childhood sleep disordered breathing

Shao-Chung Yang, Christian Nicholas, Gillian Nixon, Margot Davey, Vicki Anderson, Adrian Walker, John Trinder, Rosemary Sylvia Claire Horne

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

This study compared electroencephalogram (EEG) spectral analysis with standard visual scoring to assess the validity of clinical classification of arousals at respiratory event termination in children with obstructive sleep apnoea (OSA). METHODS: Twenty children (six M/14 F) aged 7-12 years, diagnosed with moderate to severe OSA participated in this study. Overnight polysomnography was performed, and sleep stages and arousals visually scored using clinical paediatric measures. The EEG was spectrally analysed in six 5-s epochs across respiratory events, namely two consecutive 5-s epochs pre-event onset and a 5s epoch post-event onset, 5-s before event termination, and two contiguous 5-s epochs post-event termination. EEG spectral power distribution was compared across respiratory events visually categorised as full cortical arousals, subcortical activations, or non-arousals using specialised software (Sleep Research System 5.0). RESULTS: There was no difference in power spectra between events in REM and NREM sleep and these were combined. There was a statistically significant fall from pre-arousal baseline values in delta and theta spectral power at respiratory event terminations associated with cortical arousals only. No change in power was detected at respiratory event terminations associated with subcortical activations or non-arousals. CONCLUSIONS: The lack of significant EEG spectral power changes at respiratory event terminations not associated with visually identified cortical arousals indicates undetected micro-arousals are not present. The results support the validity of clinical classifications of arousals at respiratory event termination.
Original languageEnglish
Pages (from-to)491 - 497
Number of pages7
JournalSleep and Breathing
Volume16
Issue number2
DOIs
Publication statusPublished - 2012

Cite this

Yang, Shao-Chung ; Nicholas, Christian ; Nixon, Gillian ; Davey, Margot ; Anderson, Vicki ; Walker, Adrian ; Trinder, John ; Horne, Rosemary Sylvia Claire. / EEG spectral analysis of apnoeic events confirms visual scoring in childhood sleep disordered breathing. In: Sleep and Breathing. 2012 ; Vol. 16, No. 2. pp. 491 - 497.
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title = "EEG spectral analysis of apnoeic events confirms visual scoring in childhood sleep disordered breathing",
abstract = "This study compared electroencephalogram (EEG) spectral analysis with standard visual scoring to assess the validity of clinical classification of arousals at respiratory event termination in children with obstructive sleep apnoea (OSA). METHODS: Twenty children (six M/14 F) aged 7-12 years, diagnosed with moderate to severe OSA participated in this study. Overnight polysomnography was performed, and sleep stages and arousals visually scored using clinical paediatric measures. The EEG was spectrally analysed in six 5-s epochs across respiratory events, namely two consecutive 5-s epochs pre-event onset and a 5s epoch post-event onset, 5-s before event termination, and two contiguous 5-s epochs post-event termination. EEG spectral power distribution was compared across respiratory events visually categorised as full cortical arousals, subcortical activations, or non-arousals using specialised software (Sleep Research System 5.0). RESULTS: There was no difference in power spectra between events in REM and NREM sleep and these were combined. There was a statistically significant fall from pre-arousal baseline values in delta and theta spectral power at respiratory event terminations associated with cortical arousals only. No change in power was detected at respiratory event terminations associated with subcortical activations or non-arousals. CONCLUSIONS: The lack of significant EEG spectral power changes at respiratory event terminations not associated with visually identified cortical arousals indicates undetected micro-arousals are not present. The results support the validity of clinical classifications of arousals at respiratory event termination.",
author = "Shao-Chung Yang and Christian Nicholas and Gillian Nixon and Margot Davey and Vicki Anderson and Adrian Walker and John Trinder and Horne, {Rosemary Sylvia Claire}",
year = "2012",
doi = "10.1007/s11325-011-0530-0",
language = "English",
volume = "16",
pages = "491 -- 497",
journal = "Sleep and Breathing",
issn = "1520-9512",
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Yang, S-C, Nicholas, C, Nixon, G, Davey, M, Anderson, V, Walker, A, Trinder, J & Horne, RSC 2012, 'EEG spectral analysis of apnoeic events confirms visual scoring in childhood sleep disordered breathing', Sleep and Breathing, vol. 16, no. 2, pp. 491 - 497. https://doi.org/10.1007/s11325-011-0530-0

EEG spectral analysis of apnoeic events confirms visual scoring in childhood sleep disordered breathing. / Yang, Shao-Chung; Nicholas, Christian; Nixon, Gillian; Davey, Margot; Anderson, Vicki; Walker, Adrian; Trinder, John; Horne, Rosemary Sylvia Claire.

In: Sleep and Breathing, Vol. 16, No. 2, 2012, p. 491 - 497.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - EEG spectral analysis of apnoeic events confirms visual scoring in childhood sleep disordered breathing

AU - Yang, Shao-Chung

AU - Nicholas, Christian

AU - Nixon, Gillian

AU - Davey, Margot

AU - Anderson, Vicki

AU - Walker, Adrian

AU - Trinder, John

AU - Horne, Rosemary Sylvia Claire

PY - 2012

Y1 - 2012

N2 - This study compared electroencephalogram (EEG) spectral analysis with standard visual scoring to assess the validity of clinical classification of arousals at respiratory event termination in children with obstructive sleep apnoea (OSA). METHODS: Twenty children (six M/14 F) aged 7-12 years, diagnosed with moderate to severe OSA participated in this study. Overnight polysomnography was performed, and sleep stages and arousals visually scored using clinical paediatric measures. The EEG was spectrally analysed in six 5-s epochs across respiratory events, namely two consecutive 5-s epochs pre-event onset and a 5s epoch post-event onset, 5-s before event termination, and two contiguous 5-s epochs post-event termination. EEG spectral power distribution was compared across respiratory events visually categorised as full cortical arousals, subcortical activations, or non-arousals using specialised software (Sleep Research System 5.0). RESULTS: There was no difference in power spectra between events in REM and NREM sleep and these were combined. There was a statistically significant fall from pre-arousal baseline values in delta and theta spectral power at respiratory event terminations associated with cortical arousals only. No change in power was detected at respiratory event terminations associated with subcortical activations or non-arousals. CONCLUSIONS: The lack of significant EEG spectral power changes at respiratory event terminations not associated with visually identified cortical arousals indicates undetected micro-arousals are not present. The results support the validity of clinical classifications of arousals at respiratory event termination.

AB - This study compared electroencephalogram (EEG) spectral analysis with standard visual scoring to assess the validity of clinical classification of arousals at respiratory event termination in children with obstructive sleep apnoea (OSA). METHODS: Twenty children (six M/14 F) aged 7-12 years, diagnosed with moderate to severe OSA participated in this study. Overnight polysomnography was performed, and sleep stages and arousals visually scored using clinical paediatric measures. The EEG was spectrally analysed in six 5-s epochs across respiratory events, namely two consecutive 5-s epochs pre-event onset and a 5s epoch post-event onset, 5-s before event termination, and two contiguous 5-s epochs post-event termination. EEG spectral power distribution was compared across respiratory events visually categorised as full cortical arousals, subcortical activations, or non-arousals using specialised software (Sleep Research System 5.0). RESULTS: There was no difference in power spectra between events in REM and NREM sleep and these were combined. There was a statistically significant fall from pre-arousal baseline values in delta and theta spectral power at respiratory event terminations associated with cortical arousals only. No change in power was detected at respiratory event terminations associated with subcortical activations or non-arousals. CONCLUSIONS: The lack of significant EEG spectral power changes at respiratory event terminations not associated with visually identified cortical arousals indicates undetected micro-arousals are not present. The results support the validity of clinical classifications of arousals at respiratory event termination.

UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21567337

U2 - 10.1007/s11325-011-0530-0

DO - 10.1007/s11325-011-0530-0

M3 - Article

VL - 16

SP - 491

EP - 497

JO - Sleep and Breathing

JF - Sleep and Breathing

SN - 1520-9512

IS - 2

ER -

Yang S-C, Nicholas C, Nixon G, Davey M, Anderson V, Walker A et al. EEG spectral analysis of apnoeic events confirms visual scoring in childhood sleep disordered breathing. Sleep and Breathing. 2012;16(2):491 - 497. https://doi.org/10.1007/s11325-011-0530-0

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