Editorial: Lymphatic delivery and targeting of drugs, vaccines, and imaging agents

The lymphatic system plays a key role in the (patho) physiology of a number of diseases, including autoimmune/inflammatory disorders, cancer, infections, and metabolic syndrome. Biological pathways in the lymphatic system provide new promising treatment targets for several conditions (Oliver, Kipnis et al., 2020; Petrova and Koh 2020). However, most molecules, including imaging and therapeutic agents, exhibit poor access to the lymphatics which impedes research of the lymphatic system and development of related therapies (Trevaskis, Kaminskas et al., 2015). In this Research Topic, we present a collection of primary research articles that provide new insights into the physiology of lymphatics and lymph-directed drug delivery, as well as review articles that summarize the approaches used to improve lymphatic targeting of imaging agents and drugs.