Ecionines A and B, two new cytotoxic pyridoacridine alkaloids from the Australian marine sponge, Ecionemia geodides

Emma Barnes, Nur Akmarina Said, Elizabeth Williams, John Hooper, Rohan Davis

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28 Citations (Scopus)

Abstract

Chemical investigations of the Australian marine sponge Ecionemia geodides resulted in the isolation of two new pyridoacridine alkaloids, ecionines A (1) and B (2), along with the previously isolated marine natural products, biemnadin (3) and meridine (4). Compounds 1 and 2 both contain an imine moiety, which is rare for the pyridoacridine structure class. The chemical structures of 1 and 2 were determined by extensive 1 D and 2D NMR and MS data analyses. All compounds were tested against a panel of human bladder cancer cell lines, the increasingly metastatic TSU-Pr1 series (TSU-Pr1, TSU-Pr1-B1 and TSU-Pr1-B2) and the superficial bladder cancer cell line 5637. Ecionine A (1) displayed cytotoxicity against all cell lines, with IC50 values ranging from 3 to 7 mu M. This is the first report of chemistry from the sponge genus Ecionemia. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)283 - 287
Number of pages5
JournalTetrahedron
Volume66
Issue number1
DOIs
Publication statusPublished - 2010

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