Ebola virus disease: An update on current prevention and management strategies

M. A. Trad, W. Naughton, A. Yeung, L. Mazlin, N. M. Gilroy, D. A. Fisher, R. L. Stuart

Research output: Contribution to journalReview ArticleResearchpeer-review

18 Citations (Scopus)

Abstract

Ebola virus disease (EVD) is characterised by systemic viral replication, immuno-suppression, abnormal inflammatory responses, large volume fluid and electrolyte losses, and high mortality in under-resourced settings. There are various therapeutic strategies targeting EVD including vaccines utilizing different antigen delivery methods, antibody-based therapies and antiviral drugs. These therapies remain experimental, but received attention following their use particularly in cases treated outside West Africa during the 2014–15 outbreak, in which 20 (80%) out of 25 patients survived. Emerging data from current trials look promising and are undergoing further study, however optimised supportive care remains the key to reducing mortality from EVD.

Original languageEnglish
Pages (from-to)5-13
Number of pages9
JournalJournal of Clinical Virology
Volume86
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Ebola
  • Ebolavirus
  • Management
  • Outbreak
  • Therapeutics
  • Vaccines

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