@article{1311009876c2462695b2500c216ec4a9,
title = "Early predictors of visual and axonal outcomes after acute optic neuritis",
abstract = "Background: Predicting long-term visual outcomes and axonal loss following acute optic neuritis (ON) is critical for choosing treatment. Predictive models including all clinical and paraclinical measures of optic nerve dysfunction following ON are lacking. Objectives: Using a prospective study method, to identify 1 and 3 months predictors of 6 and 12 months visual outcome (low contrast letter acuity 2.5%) and axonal loss [retinal nerve fiber layer thickness and multifocal evoked potential (mfVEP) amplitude] following acute ON. Methods: In total, 37 patients of acute ON onset were evaluated within 14 days using between-eye asymmetry of visual acuity, color vision (Ishihara plates), optical coherence tomography, mfVEP, and optic nerve magnetic resonance imaging [magnetic transfer ratio (MTR) and diffusion tensor imaging (DTI)]. Results: Visual outcome at 6 and 12 months was best predicted by Ishihara asymmetry at 1 and 3 months following ON onset. Axonal loss at 6 and 12 months was reliably predicted by Ishihara asymmetry at 1 month. Optic nerve MTR and DTI at 3 months post-acute ON could predict axonal loss at 6 and 12 months. Conclusions: Simple Ishihara asymmetry testing 1 month after acute ON onset can best predict visual outcome and axonal loss at 6 and 12 months in a clinical or research setting.",
keywords = "Ishihara, MRI, OCT, optic neuritis, prognosis",
author = "Nguyen, {Minh N.L.} and Chao Zhu and Kolbe, {Scott C.} and Helmut Butzkueven and White, {Owen B.} and Joanne Fielding and Kilpatrick, {Trevor J.} and Egan, {Gary F.} and Alexander Klistorner and {van der Walt}, Anneke",
note = "Funding Information: This research was supported by the National Health and Medical Research Council of Australia (grant 628415). Funding Information: Author HB's institution (Monash University) received compensation for consulting, talks, and advisory/steering board activities from Alfred Health, Biogen, Genzyme, Merck, and Novartis research support from Biogen, Merck, MS Research Australia, National Health and Medical Research (Australia), Novartis, the Oxford Health Policy Forum, and Roche. He has received personal compensation for steering group activities from the Oxford Health Policy Forum and Merck. Author JF has received funding from Genzyme, Biogen, and Novartis, and received honoraria from Novartis. Author TK has served on scientific advisory boards for GlaxoSmithKline, Neurosciences Victoria, and the Victorian Neurotrauma Initiative has received funding for travel from Bayer Schering pharma, Sanofi Aventis, Merck Serono, and Novartis served on the editorial board of Therapeutic Advances in Neurological Disorders is listed as an inventor on patents re: HIV test kit method for detecting anti-HIV-1 antibodies in saliva a method of modulating cell survival and reagents useful for the same. Methods for the treatment and prophylaxis of demyelinating disease and method of treatment in the field of inflammatory neurodegeneration and receives research support from Bayer Schering Pharma, Biogen IDEC. Author GE is Deputy Chairperson of the International Neuroinformatics Coordinating Facility and a member of the Neurosciences Victoria Scientific Advisory Board. He has received travel expenses and/or honoraria for lectures or educational activities not funded by industry. He is Deputy Editor in Chief of the journal Human Brain Mapping, and he serves on the editorial board of Neuroinformatics. Author AW served on advisory boards and receives unrestricted research grants from Novartis, Biogen, Merck, and Roche. She has received speaker's honoraria and travel support from Novartis, Roche, and Merck. She receives grant support from the National Health and Medical Research Council of Australia and MS Research Australia. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher Copyright: Copyright {\textcopyright} 2022 Nguyen, Zhu, Kolbe, Butzkueven, White, Fielding, Kilpatrick, Egan, Klistorner and van der Walt.",
year = "2022",
month = sep,
day = "8",
doi = "10.3389/fneur.2022.945034",
language = "English",
volume = "13",
journal = "Frontiers in Neurology",
issn = "1664-2295",
publisher = "Frontiers Media SA",
}