Early pancreas allograft thrombosis

Sharmila Ramessur; John Kanellis; Kevan R Polkinghorne; Alan Charles Saunder; William Mulley

doi:10.1111/ctr.12105

Early pancreas allograft thrombosis

Sharmila Ramessur, John Kanellis, Kevan R Polkinghorne, Alan Charles Saunder, William Mulley

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12 Citations (Scopus)

Abstract

OBJECTIVES: To determine factors associated with early pancreatic allograft thrombosis (EPAT). Thrombosis is the leading non-immunological cause of early pancreatic allograft failure. Multiple risk factors have been postulated. We hypothesized that recipient perioperative hypotension was a major risk factor and evaluated the correlation of this and other parameters with EPAT. METHODS: We retrospectively reviewed the records of the 118 patients who received a pancreatic allograft at our center between October 1992 and January 2010. Multiple donor and recipient parameters were analyzed as associates of EPAT by univariate and multivariate analysis. RESULTS: There were 12 episodes of EPAT, resulting in an incidence of 10.2 . On univariate analysis, EPAT was associated with perioperative hypotension, vasopressor use, and neuropathy in the recipient (p

Original language	English
Pages (from-to)	410 - 416
Number of pages	7
Journal	Clinical Transplantation
Volume	27
Issue number	3
DOIs	https://doi.org/10.1111/ctr.12105
Publication status	Published - 2013

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10.1111/ctr.12105

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title = "Early pancreas allograft thrombosis",

abstract = "OBJECTIVES: To determine factors associated with early pancreatic allograft thrombosis (EPAT). Thrombosis is the leading non-immunological cause of early pancreatic allograft failure. Multiple risk factors have been postulated. We hypothesized that recipient perioperative hypotension was a major risk factor and evaluated the correlation of this and other parameters with EPAT. METHODS: We retrospectively reviewed the records of the 118 patients who received a pancreatic allograft at our center between October 1992 and January 2010. Multiple donor and recipient parameters were analyzed as associates of EPAT by univariate and multivariate analysis. RESULTS: There were 12 episodes of EPAT, resulting in an incidence of 10.2 . On univariate analysis, EPAT was associated with perioperative hypotension, vasopressor use, and neuropathy in the recipient (p",

author = "Sharmila Ramessur and John Kanellis and Polkinghorne, {Kevan R} and Saunder, {Alan Charles} and William Mulley",

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doi = "10.1111/ctr.12105",

language = "English",

volume = "27",

pages = "410 -- 416",

journal = "Clinical Transplantation",

issn = "1399-0012",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Early pancreas allograft thrombosis

AU - Ramessur, Sharmila

AU - Kanellis, John

AU - Polkinghorne, Kevan R

AU - Saunder, Alan Charles

AU - Mulley, William

PY - 2013

Y1 - 2013

N2 - OBJECTIVES: To determine factors associated with early pancreatic allograft thrombosis (EPAT). Thrombosis is the leading non-immunological cause of early pancreatic allograft failure. Multiple risk factors have been postulated. We hypothesized that recipient perioperative hypotension was a major risk factor and evaluated the correlation of this and other parameters with EPAT. METHODS: We retrospectively reviewed the records of the 118 patients who received a pancreatic allograft at our center between October 1992 and January 2010. Multiple donor and recipient parameters were analyzed as associates of EPAT by univariate and multivariate analysis. RESULTS: There were 12 episodes of EPAT, resulting in an incidence of 10.2 . On univariate analysis, EPAT was associated with perioperative hypotension, vasopressor use, and neuropathy in the recipient (p

AB - OBJECTIVES: To determine factors associated with early pancreatic allograft thrombosis (EPAT). Thrombosis is the leading non-immunological cause of early pancreatic allograft failure. Multiple risk factors have been postulated. We hypothesized that recipient perioperative hypotension was a major risk factor and evaluated the correlation of this and other parameters with EPAT. METHODS: We retrospectively reviewed the records of the 118 patients who received a pancreatic allograft at our center between October 1992 and January 2010. Multiple donor and recipient parameters were analyzed as associates of EPAT by univariate and multivariate analysis. RESULTS: There were 12 episodes of EPAT, resulting in an incidence of 10.2 . On univariate analysis, EPAT was associated with perioperative hypotension, vasopressor use, and neuropathy in the recipient (p

UR - http://www.ncbi.nlm.nih.gov/pubmed/23495654

U2 - 10.1111/ctr.12105

DO - 10.1111/ctr.12105

M3 - Article

VL - 27

SP - 410

EP - 416

JO - Clinical Transplantation

JF - Clinical Transplantation

SN - 1399-0012

IS - 3

ER -