@article{0629307203854b42bd82b4b442b54195,
title = "Early onset diagnosis in Alzheimer{\textquoteright}s disease patients via amyloid-β oligomers-sensing probe in cerebrospinal fluid",
abstract = "Amyloid-β (Aβ) oligomers are implicated in the onset of Alzheimer{\textquoteright}s disease (AD). Herein, quinoline-derived half-curcumin-dioxaborine (Q-OB) fluorescent probe was designed for detecting Aβ oligomers by finely tailoring the hydrophobicity of the biannulate donor motifs in donor-π-acceptor structure. Q-OB shows a great sensing potency in dynamically monitoring oligomerization of Aβ during amyloid fibrillogenesis in vitro. In addition, we applied this strategy to fluorometrically analyze Aβ self-assembly kinetics in the cerebrospinal fluids (CSF) of AD patients. The fluorescence intensity of Q-OB in AD patients{\textquoteright} CSF revealed a marked change of log (I/I0) value of 0.34 ± 0.13 (cognitive normal), 0.15 ± 0.12 (mild cognitive impairment), and 0.14 ± 0.10 (AD dementia), guiding to distinguish a state of AD continuum for early diagnosis of AD. These studies demonstrate the potential of our approach can expand the currently available preclinical diagnostic platform for the early stages of AD, aiding in the disruption of pathological progression and the development of appropriate treatment strategies.",
author = "Jusung An and Kyeonghwan Kim and Lim, \{Ho Jae\} and Kim, \{Hye Yun\} and Jinwoo Shin and Park, \{In Wook\} and Illhwan Cho and Kim, \{Hyeong Yun\} and Sunghoon Kim and Catriona McLean and Choi, \{Kyu Yeong\} and Kim, \{Young Soo\} and Lee, \{Kun Ho\} and Kim, \{Jong Seung\}",
note = "Funding Information: All the clinical data and CSF samples were provided by the Gwangju Alzheimer{\textquoteright}s \& Related Dementia Cohort Center (Gwangju, Korea). The human cerebral hippocampal tissue specimens were received from the Victorian Brain Bank Network (VBBN), supported by The Florey, The Alfred and the Victorian Institute of Forensic Medicine and funded in part by Parkinson{\textquoteright}s Victoria, MND Victoria and FightMND (Australia). This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. RS-2023-00273030, J.A.), by the Ministry of Health \& Welfare and Ministry of Science and ICT (CRI project No. 2018R1A3B1052702, J.S.K.), by the Original Technology Research Program for Brain Science of the NRF, MSIT (No. NRF-2014M3C7A1046041, K.H.L.), by Mid-Career Researcher Program (No. NRF-2021R1A2C2093916, Y.K.), by the Basic Research Program through the Korea Brain Research Institute (KBRI) funded by Ministry of Science and ICT (No. 23-BR-03-05, K.H. L.), and by the Healthcare AI Convergence Research \& Development Program through the National IT Industry Promotion Agency of Korea (NIPA) funded by the Ministry of Science and ICT (No. 1711171057, K.H.L.). Funding Information: All the clinical data and CSF samples were provided by the Gwangju Alzheimer{\textquoteright}s \& Related Dementia Cohort Center (Gwangju, Korea). The human cerebral hippocampal tissue specimens were received from the Victorian Brain Bank Network (VBBN), supported by The Florey, The Alfred and the Victorian Institute of Forensic Medicine and funded in part by Parkinson{\textquoteright}s Victoria, MND Victoria and FightMND (Australia). This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. RS-2023-00273030, J.A.), by the Ministry of Health \& Welfare and Ministry of Science and ICT (CRI project No. 2018R1A3B1052702, J.S.K.), by the Original Technology Research Program for Brain Science of the NRF, MSIT (No. NRF-2014M3C7A1046041, K.H.L.), by Mid-Career Researcher Program (No. NRF-2021R1A2C2093916, Y.K.), by the Basic Research Program through the Korea Brain Research Institute (KBRI) funded by Ministry of Science and ICT (No. 23-BR-03-05, K.H. L.), and by the Healthcare AI Convergence Research \& Development Program through the National IT Industry Promotion Agency of Korea (NIPA) funded by the Ministry of Science and ICT (No. 1711171057, K.H.L.). Publisher Copyright: {\textcopyright} The Author(s) 2024.",
year = "2024",
month = dec,
doi = "10.1038/s41467-024-44818-x",
language = "English",
volume = "15",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}