Early myeloid cells expressing c-KIT isoforms differ in signal transduction, survival and chemotactic responses to Stem Cell Factor

Sonia McCallum, Anthony Cambareri, Adam Odell, Sean Geary, Leonie Ashman

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Isoforms of the receptor tyrosine kinase, c-KIT, differ in the presence or absence of a GNNK tetrapeptide in the extracellular juxtamembrane region. When expressed in murine NIH3T3 cells, these isoforms of c-KIT showed differential activation of signaling pathways and proliferation in response to Stem Cell Factor.
Original languageEnglish
Pages (from-to)2572 - 2581
Number of pages9
JournalCellular Signalling
Volume19
Publication statusPublished - 2007

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