Early MRI in term infants with perinatal hypoxic-ischaemic brain injury: interobserver agreement and MRI predictors of outcome at 2 years

Stacy Kellan Goergen, Hazel Ang, Flora Yuen-Wait Wong, Elizabeth A Carse, Margaret Charlton, Rachel Evans, Graham Whiteley, Jenni Clark, David Shipp, Damien John Jolley, Eldho Paul, Jeanie Ling Yoong Cheong

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Aim To compare diffusion-weighted imaging (DWI) and non-DWI magnetic resonance imaging (MRI), proton MR spectroscopy (1H-MRS), and clinical biomarkers for prediction of 2 year developmental outcome in term infants with perinatal hypoxic-ischaemic encephalopathy (HIE). Materials and methods Nineteen infants =36 weeks gestation with HIE were recruited and MRI performed day 3-7 (mean = 5). MRI was scored independently by three radiologists using a standardized scoring system. Lactate-to-N-acetylaspartate ratio (Lac:NAA) in the lentiform nucleus was calculated. Developmental assessment was performed at 2 years using the Bayley Scales of Infant and Toddler Development (BSID-III). Interobserver agreement about abnormality in 10 brain regions was measured. Univariate analysis was performed to determine variables associated with adverse outcome (i.e., death or Bayley score for any domain
Original languageEnglish
Pages (from-to)72 - 81
Number of pages10
JournalClinical Radiology
Issue number1
Publication statusPublished - 2014

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