TY - JOUR
T1 - Early MRI in term infants with perinatal hypoxic-ischaemic brain injury: interobserver agreement and MRI predictors of outcome at 2 years
AU - Goergen, Stacy Kellan
AU - Ang, Hazel
AU - Wong, Flora Yuen-Wait
AU - Carse, Elizabeth A
AU - Charlton, Margaret
AU - Evans, Rachel
AU - Whiteley, Graham
AU - Clark, Jenni
AU - Shipp, David
AU - Jolley, Damien John
AU - Paul, Eldho
AU - Cheong, Jeanie Ling Yoong
PY - 2014
Y1 - 2014
N2 - Aim To compare diffusion-weighted imaging (DWI) and non-DWI magnetic resonance imaging (MRI), proton MR spectroscopy (1H-MRS), and clinical biomarkers for prediction of 2 year developmental outcome in term infants with perinatal hypoxic-ischaemic encephalopathy (HIE). Materials and methods Nineteen infants =36 weeks gestation with HIE were recruited and MRI performed day 3-7 (mean = 5). MRI was scored independently by three radiologists using a standardized scoring system. Lactate-to-N-acetylaspartate ratio (Lac:NAA) in the lentiform nucleus was calculated. Developmental assessment was performed at 2 years using the Bayley Scales of Infant and Toddler Development (BSID-III). Interobserver agreement about abnormality in 10 brain regions was measured. Univariate analysis was performed to determine variables associated with adverse outcome (i.e., death or Bayley score for any domain
AB - Aim To compare diffusion-weighted imaging (DWI) and non-DWI magnetic resonance imaging (MRI), proton MR spectroscopy (1H-MRS), and clinical biomarkers for prediction of 2 year developmental outcome in term infants with perinatal hypoxic-ischaemic encephalopathy (HIE). Materials and methods Nineteen infants =36 weeks gestation with HIE were recruited and MRI performed day 3-7 (mean = 5). MRI was scored independently by three radiologists using a standardized scoring system. Lactate-to-N-acetylaspartate ratio (Lac:NAA) in the lentiform nucleus was calculated. Developmental assessment was performed at 2 years using the Bayley Scales of Infant and Toddler Development (BSID-III). Interobserver agreement about abnormality in 10 brain regions was measured. Univariate analysis was performed to determine variables associated with adverse outcome (i.e., death or Bayley score for any domain
UR - http://goo.gl/YRFtjX
U2 - 10.1016/j.crad.2013.09.001
DO - 10.1016/j.crad.2013.09.001
M3 - Article
SN - 0009-9260
VL - 69
SP - 72
EP - 81
JO - Clinical Radiology
JF - Clinical Radiology
IS - 1
ER -