Early-life risk factors for childhood wheeze phenotypes in a high-risk birth cohort

Caroline J Lodge, Sophie Zaloumis, Adrian J Lowe, Lyle C Gurrin, Melanie C Matheson, Christine Axelrad, Catherine Bennett, David J Hill, Clifford S Hosking, Cecilie Svanes, Michael John Abramson, Katrina J Allen, Shyamali C Dharmage

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Abstract

Objective: To define longitudinal childhood wheeze phenotypes and identify their early-life risk factors. Study design: Current wheeze was recorded 23 times up to age 7 years in a birth cohort at high risk for allergy (n = 620). Latent class analysis of wheeze responses identified 5 classes. Multinomial logistic regression estimated associations of probability-weighted wheezing classes with early-life factors. All phenotypes were compared with never/infrequent wheezers. Results: Lower respiratory tract infection (LRTI) by 1 year (relative risk [RR], 3.00; 95 CI, 1.58-5.70), childcare by 1 year (RR, 1.51; 95 CI, 1.02-2.22), and higher body mass index (RR, 2.51; 95 CI, 1.09-5.81) were associated with increased risk of early transient wheeze, whereas breastfeeding was protective (RR, 0.54; 95 CI, 0.32-0.90). LRTI (RR, 6.54; 95 CI, 2.55-16.76) and aeroallergen sensitization (RR, 4.95; 95 CI, 1.74-14.02) increased the risk of early persistent wheeze. LRTI (RR, 5.31; 95 CI, 2.71-10.41), eczema (RR, 2.77; 95 CI, 1.78-4.31), aeroallergen sensitization (RR, 5.60; 95 CI, 2.86-10.9), and food sensitization (RR, 2.77; 95 CI, 1.56-4.94) increased the risk of intermediate-onset wheeze, whereas dog exposure at baseline (RR, 0.52; 95 CI, 0.32-0.84) and first-born status (RR, 0.49; 95 CI, 0.32-0.76) were protective. Heavy parental smoking at birth (RR, 3.18; 95 CI, 1.02-9.88) increased the risk of late-onset wheeze, whereas breastfeeding reduced it (RR, 0.34; 95 CI, 0.12-0.96). All wheeze classes except early transient had greater risk of wheeze at age 12 years compared with never/infrequent wheezers. Conclusion: We found distinct early-life risk factor profiles for each wheeze phenotype.
Original languageEnglish
Pages (from-to)289 - 294e1-2
Number of pages8
JournalJournal of Pediatrics
Volume164
Issue number2
DOIs
Publication statusPublished - 2014

Cite this

Lodge, C. J., Zaloumis, S., Lowe, A. J., Gurrin, L. C., Matheson, M. C., Axelrad, C., ... Dharmage, S. C. (2014). Early-life risk factors for childhood wheeze phenotypes in a high-risk birth cohort. Journal of Pediatrics, 164(2), 289 - 294e1-2. https://doi.org/10.1016/j.jpeds.2013.09.056
Lodge, Caroline J ; Zaloumis, Sophie ; Lowe, Adrian J ; Gurrin, Lyle C ; Matheson, Melanie C ; Axelrad, Christine ; Bennett, Catherine ; Hill, David J ; Hosking, Clifford S ; Svanes, Cecilie ; Abramson, Michael John ; Allen, Katrina J ; Dharmage, Shyamali C. / Early-life risk factors for childhood wheeze phenotypes in a high-risk birth cohort. In: Journal of Pediatrics. 2014 ; Vol. 164, No. 2. pp. 289 - 294e1-2.
@article{a45f21d3343242d090d55bb6360b1550,
title = "Early-life risk factors for childhood wheeze phenotypes in a high-risk birth cohort",
abstract = "Objective: To define longitudinal childhood wheeze phenotypes and identify their early-life risk factors. Study design: Current wheeze was recorded 23 times up to age 7 years in a birth cohort at high risk for allergy (n = 620). Latent class analysis of wheeze responses identified 5 classes. Multinomial logistic regression estimated associations of probability-weighted wheezing classes with early-life factors. All phenotypes were compared with never/infrequent wheezers. Results: Lower respiratory tract infection (LRTI) by 1 year (relative risk [RR], 3.00; 95 CI, 1.58-5.70), childcare by 1 year (RR, 1.51; 95 CI, 1.02-2.22), and higher body mass index (RR, 2.51; 95 CI, 1.09-5.81) were associated with increased risk of early transient wheeze, whereas breastfeeding was protective (RR, 0.54; 95 CI, 0.32-0.90). LRTI (RR, 6.54; 95 CI, 2.55-16.76) and aeroallergen sensitization (RR, 4.95; 95 CI, 1.74-14.02) increased the risk of early persistent wheeze. LRTI (RR, 5.31; 95 CI, 2.71-10.41), eczema (RR, 2.77; 95 CI, 1.78-4.31), aeroallergen sensitization (RR, 5.60; 95 CI, 2.86-10.9), and food sensitization (RR, 2.77; 95 CI, 1.56-4.94) increased the risk of intermediate-onset wheeze, whereas dog exposure at baseline (RR, 0.52; 95 CI, 0.32-0.84) and first-born status (RR, 0.49; 95 CI, 0.32-0.76) were protective. Heavy parental smoking at birth (RR, 3.18; 95 CI, 1.02-9.88) increased the risk of late-onset wheeze, whereas breastfeeding reduced it (RR, 0.34; 95 CI, 0.12-0.96). All wheeze classes except early transient had greater risk of wheeze at age 12 years compared with never/infrequent wheezers. Conclusion: We found distinct early-life risk factor profiles for each wheeze phenotype.",
author = "Lodge, {Caroline J} and Sophie Zaloumis and Lowe, {Adrian J} and Gurrin, {Lyle C} and Matheson, {Melanie C} and Christine Axelrad and Catherine Bennett and Hill, {David J} and Hosking, {Clifford S} and Cecilie Svanes and Abramson, {Michael John} and Allen, {Katrina J} and Dharmage, {Shyamali C}",
year = "2014",
doi = "10.1016/j.jpeds.2013.09.056",
language = "English",
volume = "164",
pages = "289 -- 294e1--2",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby International",
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}

Lodge, CJ, Zaloumis, S, Lowe, AJ, Gurrin, LC, Matheson, MC, Axelrad, C, Bennett, C, Hill, DJ, Hosking, CS, Svanes, C, Abramson, MJ, Allen, KJ & Dharmage, SC 2014, 'Early-life risk factors for childhood wheeze phenotypes in a high-risk birth cohort', Journal of Pediatrics, vol. 164, no. 2, pp. 289 - 294e1-2. https://doi.org/10.1016/j.jpeds.2013.09.056

Early-life risk factors for childhood wheeze phenotypes in a high-risk birth cohort. / Lodge, Caroline J; Zaloumis, Sophie; Lowe, Adrian J; Gurrin, Lyle C; Matheson, Melanie C; Axelrad, Christine; Bennett, Catherine; Hill, David J; Hosking, Clifford S; Svanes, Cecilie; Abramson, Michael John; Allen, Katrina J; Dharmage, Shyamali C.

In: Journal of Pediatrics, Vol. 164, No. 2, 2014, p. 289 - 294e1-2.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Early-life risk factors for childhood wheeze phenotypes in a high-risk birth cohort

AU - Lodge, Caroline J

AU - Zaloumis, Sophie

AU - Lowe, Adrian J

AU - Gurrin, Lyle C

AU - Matheson, Melanie C

AU - Axelrad, Christine

AU - Bennett, Catherine

AU - Hill, David J

AU - Hosking, Clifford S

AU - Svanes, Cecilie

AU - Abramson, Michael John

AU - Allen, Katrina J

AU - Dharmage, Shyamali C

PY - 2014

Y1 - 2014

N2 - Objective: To define longitudinal childhood wheeze phenotypes and identify their early-life risk factors. Study design: Current wheeze was recorded 23 times up to age 7 years in a birth cohort at high risk for allergy (n = 620). Latent class analysis of wheeze responses identified 5 classes. Multinomial logistic regression estimated associations of probability-weighted wheezing classes with early-life factors. All phenotypes were compared with never/infrequent wheezers. Results: Lower respiratory tract infection (LRTI) by 1 year (relative risk [RR], 3.00; 95 CI, 1.58-5.70), childcare by 1 year (RR, 1.51; 95 CI, 1.02-2.22), and higher body mass index (RR, 2.51; 95 CI, 1.09-5.81) were associated with increased risk of early transient wheeze, whereas breastfeeding was protective (RR, 0.54; 95 CI, 0.32-0.90). LRTI (RR, 6.54; 95 CI, 2.55-16.76) and aeroallergen sensitization (RR, 4.95; 95 CI, 1.74-14.02) increased the risk of early persistent wheeze. LRTI (RR, 5.31; 95 CI, 2.71-10.41), eczema (RR, 2.77; 95 CI, 1.78-4.31), aeroallergen sensitization (RR, 5.60; 95 CI, 2.86-10.9), and food sensitization (RR, 2.77; 95 CI, 1.56-4.94) increased the risk of intermediate-onset wheeze, whereas dog exposure at baseline (RR, 0.52; 95 CI, 0.32-0.84) and first-born status (RR, 0.49; 95 CI, 0.32-0.76) were protective. Heavy parental smoking at birth (RR, 3.18; 95 CI, 1.02-9.88) increased the risk of late-onset wheeze, whereas breastfeeding reduced it (RR, 0.34; 95 CI, 0.12-0.96). All wheeze classes except early transient had greater risk of wheeze at age 12 years compared with never/infrequent wheezers. Conclusion: We found distinct early-life risk factor profiles for each wheeze phenotype.

AB - Objective: To define longitudinal childhood wheeze phenotypes and identify their early-life risk factors. Study design: Current wheeze was recorded 23 times up to age 7 years in a birth cohort at high risk for allergy (n = 620). Latent class analysis of wheeze responses identified 5 classes. Multinomial logistic regression estimated associations of probability-weighted wheezing classes with early-life factors. All phenotypes were compared with never/infrequent wheezers. Results: Lower respiratory tract infection (LRTI) by 1 year (relative risk [RR], 3.00; 95 CI, 1.58-5.70), childcare by 1 year (RR, 1.51; 95 CI, 1.02-2.22), and higher body mass index (RR, 2.51; 95 CI, 1.09-5.81) were associated with increased risk of early transient wheeze, whereas breastfeeding was protective (RR, 0.54; 95 CI, 0.32-0.90). LRTI (RR, 6.54; 95 CI, 2.55-16.76) and aeroallergen sensitization (RR, 4.95; 95 CI, 1.74-14.02) increased the risk of early persistent wheeze. LRTI (RR, 5.31; 95 CI, 2.71-10.41), eczema (RR, 2.77; 95 CI, 1.78-4.31), aeroallergen sensitization (RR, 5.60; 95 CI, 2.86-10.9), and food sensitization (RR, 2.77; 95 CI, 1.56-4.94) increased the risk of intermediate-onset wheeze, whereas dog exposure at baseline (RR, 0.52; 95 CI, 0.32-0.84) and first-born status (RR, 0.49; 95 CI, 0.32-0.76) were protective. Heavy parental smoking at birth (RR, 3.18; 95 CI, 1.02-9.88) increased the risk of late-onset wheeze, whereas breastfeeding reduced it (RR, 0.34; 95 CI, 0.12-0.96). All wheeze classes except early transient had greater risk of wheeze at age 12 years compared with never/infrequent wheezers. Conclusion: We found distinct early-life risk factor profiles for each wheeze phenotype.

UR - http://www.sciencedirect.com/science/article/pii/S0022347613012274

U2 - 10.1016/j.jpeds.2013.09.056

DO - 10.1016/j.jpeds.2013.09.056

M3 - Article

VL - 164

SP - 289 - 294e1-2

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 2

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Lodge CJ, Zaloumis S, Lowe AJ, Gurrin LC, Matheson MC, Axelrad C et al. Early-life risk factors for childhood wheeze phenotypes in a high-risk birth cohort. Journal of Pediatrics. 2014;164(2):289 - 294e1-2. https://doi.org/10.1016/j.jpeds.2013.09.056