Early life programming of cardiometabolic disease in the Western Australian pregnancy cohort (Raine) study

Rae-Chi Huang, Trevor A. Mori, Lawrence J. Beilin

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Abstract

The Raine study (http://www.rainestudy.org.au, accessed 18 June 2012) is a longitudinal Australian birth cohort that has serially assessed the offspring of 2900 pregnant women from 18 weeks gestation in utero to 17 years of age. The Raine study data have shown that low birth weight is a surrogate for poor in utero growth from 18 weeks gestation. A U-shaped relationship between birth size and cardiometabolic risk exists in this Western Australian cohort, implying that both low and high birth weight are associated with increased risk. High birth weight is a risk factor for cardiometabolic risk, particularly for females. Lifetime adiposity trajectories are better at predicting metabolic risk of the offspring than birth size or current body mass index. Therefore, early life programming is an ongoing process, starting in utero and undergoing at least some level of modification in parallel with changes in adiposity during early childhood. Maternal smoking during pregnancy, maternal obesity, hypertension and diabetes increase the risk for metabolic risk in the offspring. Breast feeding is protective for cardiometabolic risk in this Australian cohort.

Original languageEnglish
Pages (from-to)973-978
Number of pages6
JournalClinical and Experimental Pharmacology and Physiology
Volume39
Issue number11
DOIs
Publication statusPublished - Nov 2012
Externally publishedYes

Keywords

  • Cardiovascular risk factor
  • Fetal programming
  • Metabolic syndrome
  • Raine study

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