@article{8db04fcd2aaf403bb6bdcac6d3ce8daf,
title = "Early-life exposure to Tris(1,3-dichloroisopropyl) phosphate induces dose-dependent suppression of sexual behavior in male rats",
abstract = " Exposure to endocrine-disrupting chemicals may adversely affect animals, particularly during development. Tris(1,3-dichloroisopropyl) phosphate (TDCIPP) is an organophosphate with anti-androgen function in vitro that is present in indoor dust at relatively high concentrations. In male rats, androgens are necessary for the development of reproductive organs, as well as the endocrine and central nervous systems. However, we currently do not know the exact effects of TDCIPP exposure through suckling on subsequent reproductive behavior in males. Here, we show that TDCIPP exposure (25–250 mg kg –1 via oral administration over 28 consecutive days post-birth) suppressed male sexual behavior and reduced testes size. These changes were dose-dependent and appeared first in adults rather than in juveniles. These results demonstrate that TDCIPP exposure led to normal body growth and appearance in juveniles, but disrupted the endocrine system and physiology in adults. Therefore, assays should be performed using adult animals to ensure accuracy, and to confirm the influence of chemical substances given during early mammalian life. ",
keywords = "Early-life exposure, Endocrine-disrupting chemical, Male sexual behavior, Oral administration, Plasma testosterone, Residual chemical substrate, TDCIPP",
author = "Manami Kamishima and Tatsuya Hattori and Go Suzuki and Hidenori Matsukami and Chiaki Komine and Yasuyuki Horii and Gen Watanabe and Takumi Oti and Hirotaka Sakamoto and Tomoko Soga and Parhar, {Ishwar S.} and Yasuhiko Kondo and Hidetaka Takigami and Maiko Kawaguchi",
note = "Funding Information: We thank the members of the Laboratory of Animal Behavior and Environmental Science (Meiji University) for assistance with behavioral tests. This study was supported in part by Grants‐in‐Aid for Young Scientists (A) (grant no. 23681011 to G.S.) from the Japan Society for the Promotion of Science (JSPS) and Environment Research and Technology Development Fund (grant no. 3 K153001 to H.T.) of the Ministry of the Environment, Japan. This paper is dedicated to Dr. Hidetaka Takigami, who passed away during the preparation of the manuscript. Funding Information: We thank the members of the Laboratory of Animal Behavior and Environmental Science (Meiji University) for assistance with behavioral tests. This study was supported in part by Grants-in-Aid for Young Scientists (A) (grant no. 23681011 to G.S.) from the Japan Society for the Promotion of Science (JSPS) and Environment Research and Technology Development Fund (grant no. 3?K153001 to H.T.) of the Ministry of the Environment, Japan. This paper is dedicated to Dr. Hidetaka Takigami, who passed away during the preparation of the manuscript. Publisher Copyright: Copyright {\textcopyright} 2017 John Wiley & Sons, Ltd. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2018",
month = may,
doi = "10.1002/jat.3569",
language = "English",
volume = "38",
pages = "649--655",
journal = "Journal of Applied Toxicology",
issn = "0260-437X",
publisher = "John Wiley & Sons",
number = "5",
}