Early intervention, prevention, and prediction in mood disorders: Tracking multidimensional outcomes in young people presenting for mental health care

Elizabeth M. Scott, Joanne S. Carpenter, Frank Iorfino, Shane P.M. Cross, Daniel F. Hermens, Django White, Rico S.Z. Lee, Sharon L. Naismith, Adam J. Guastella, Nicholas Glozier, F. Markus Leweke, Dagmar Koethe, Jim Lagopoulos, Jan Scott, Blake A. Hamilton, Jacob J. Crouse, Ashleigh M. Tickell, Alissa Nichles, Natalia Zmicerevska, Lillian J. GehueManreena Kaur, Kate M. Chitty, Ian B. Hickie

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4 Citations (Scopus)


A key population-health priority is to reduce the rates of premature death and illness burden due to the common anxiety and mood disorders that typically have their onset during adolescence and early-adult years. From an individual clinical and health services planning perspective, evidence relating to the potential impacts of early identification, secondary prevention, and enhanced long-term care strategies is required. Over the past decade, we have accumulated substantial cross-sectional and longitudinal evidence from a cohort of more than 7000 individuals detailing how these types of services can be developed, structured, and evaluated for young people with emerging mood disorders. A clear conclusion is that impairment and concurrent morbidity is well-established in these young people (mean age 18years) by the time they present for mental health-focused care. A clear caveat, however, is that early identification, followed by standard care, does not automatically result in improved outcomes. While much work is yet to be done in the development of individual-level and service-level care packages to reduce morbidity and mortality, our key findings support the utility of clinical staging as an adjunct to traditional diagnostic frameworks, the recognition of at least three pathophysiological underlying paths (resulting in different age-dependent phenotypes in childhood and adolescence), and a strong focus on implementing a genuinely multidimensional assessment and longitudinal outcomes framework.

Original languageEnglish
Title of host publicationPersonalized Psychiatry
EditorsBernhard T. Baune
Place of PublicationUnited Kingdom
PublisherAcademic Press
Number of pages24
ISBN (Electronic)9780128131763
ISBN (Print)9780128131770
Publication statusPublished - 2020
Externally publishedYes


  • Depression
  • Early intervention
  • Mood disorders
  • Prevention
  • Suicide

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